不同性别老年人群身体圆度指数与体质量正常代谢异常表型的相关性研究:以三酰甘油葡萄糖乘积指数为潜在影响因素  

Study on the Correlation between Body Roundness Index and Metabolically Obese Normal Weight Phenotype in an Elderly Population of Different Genders:Triglyceride Glucose Index as a Potential Influencing Factor

作　　者：傅方琳 潘姚佳 韩正 孙梦 顾怀聪 王为强[1] FU Fanglin;PAN Yaojia;HAN Zheng;SUN Meng;GU Huaicong;WANG Weiqiang(Department of General Medicine,Suzhou Hospital Affiliated to Anhui Medical University/Suzhou Municipal Hospital of Anhui Province,Suzhou 234000,China;Anhui Medical University,Hefei 230000,China)

机构地区：[1]安徽医科大学附属宿州医院,安徽省宿州市立医院全科医学科,安徽省宿州市234000 [2]安徽医科大学,安徽省合肥市230000

出　　处：《中国全科医学》2024年第30期3746-3752,3757,共8页Chinese General Practice

基　　金：2021年度安徽省科技创新战略与软科学研究专项计划项目(202106f050042)。

摘　　要：背景身体圆度指数(BRI)是一种衡量中心性肥胖的简易指标,与心血管疾病密切相关。体质量正常代谢异常(MONW)人群患心血管疾病的风险较高,且与中心性肥胖显著相关。三酰甘油葡萄糖乘积(TyG)指数是反映胰岛素抵抗的指标。目前在不同性别老年人群中BRI、TyG指数和MONW表型的关系研究较为有限。目的探讨老年人群BRI与MONW表型患病风险在不同性别中的差异,探究TyG指数作为其不同性别中差异的潜在因素。方法选取2017-07-01—2021-06-30在安徽省10个市县区体检的≥60岁的常住居民为研究对象。采用统一的调查表收集研究对象的性别、年龄、疾病史等资料,收集体格检查和实验室检查资料,并计算BRI、TyG指数。将根据代谢状态和BMI水平分别将男性和女性分为体质量正常代谢正常(MHNW)表型和MONW表型:男性MHNW表型(n=5384)、男性MONW表型(n=6251);女性MHNW表型(n=4498)、女性MONW表型(n=8264)。根据BRI四分位数分别将男性和女性分为4个水平,即男性:M1、M2、M3、M4,女性:F1、F2、F3、F4。采用Logistic回归分析分别探讨BRI四分位水平与TyG指数升高风险以及MONW表型患病风险的关系,采用R(version 4.1.1)软件中的Z检验比较男性和女性OR值之间的差异。结果本研究共纳入24397例调查对象,其中男11635例(47.7%)、女12762例(52.3%),中位年龄67(64,70)岁,MHNW表型9882例(40.5%)、MONW表型14515例(59.5%)。不同性别MONW表型老年人群高血压比例、糖尿病比例、血脂异常比例、收缩压、舒张压、TyG指数、BRI、空腹血糖(FPG)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)高于MHNW表型,吸烟比例、高密度脂蛋白胆固醇(HDL-C)低于MHNW表型(P<0.05);不同性别高水平BRI老年人群MONW表型患病、高血压比例、糖尿病比例、血脂异常比例、TyG指数、FPG、TG高于低水平BRI,HDL-C低于低水平BRI(P<0.05)。单因素Logistic回归分析结果显示,�Background Body roundness index(BRI)is a simple measure of central obesity and is strongly associated with cardiovascular disease.People with metabolically obese normal weight(MONW)have a higher risk of cardiovascular disease and are significantly associated with central obesity.The triglyceride glucose(TyG)index is an indicator of insulin resistance.There are limited studies on the relationship between BRI,TyG index and MONW phenotypes in gender-specific elderly populations.Objective To explore differences in the risk of prevalence of the BRI and MONW phenotypes in the elderly population by gender,and to explore the TyG index as a potential factor in their differences by gender.Methods Permanent residents≥60 years of age who underwent physical examination in 10 cities and counties in Anhui Province from 2017-07-01 to 2021-06-30 were selected as study subjects.A unified questionnaire was used to collect information on gender,age,and disease history of the study subjects,collect information on physical examination and laboratory tests,and calculate BRI and TyG indices.Men and women will be classified into metabolically healthy normal weight(MHNW)phenotype and MONW phenotype according to metabolic status and BMI level,respectively:male MHNW phenotype(n=5384),male MONW phenotype(n=6251);female MHNW phenotype(n=4498),female MONW phenotype(n=8264).Males and females were divided into 4 levels according to BRI quartiles,males:M1,M2,M3,and M4,and females:F1,F2,F3,and F4,respectively.Logistic regression analyses were performed to explore the association between BRI quartile levels and the risk of elevated TyG index and the risk of prevalence of MONW phenotypes respectively,using the Z test was used to compare the differences between the OR value of male and female.Results A total of 24397 investigators were included in this study,including 11635(47.7%)males and 12762(52.3%)females,with a median age of 67(64,70)years,and 9882(40.5%)with MHNW phenotype and 14515(59.5%)with MONW phenotype.The proportion of hypertension,dia

关 键 词：身体圆度指数 体质量正常代谢异常表型 三酰甘油葡萄糖乘积指数 性别 老年人 中心性肥胖 相关性研究 

分 类 号：R589[医药卫生—内分泌]