硫酸镁在围手术期麻醉实践中的研究进展  

Research progress of magnesium sulfate in perioperative anesthesia practice

作　　者：徐海(综述) 刘莺歌 王雨欣 王馨馨 张小宝(审校) XU Hai;LIU Yingge;WANG Yuxin;WANG Xinxin;ZHANG Xiaobao(Jinzhou Medical University,Jinzhou,Liaoning 121001,China;Lianyungang Clinical Medical College,Nanjing Medical University,Lianyungang,Jiangsu 222000,China;Department of Anesthesiology,Lianyungang Hospital Affiliated to Xuzhou Medical University,Lianyungang,Jiangsu 222000,China;Department of Anesthesiology,First Affiliated Hospital of Kangda College,Nanjing Medical University,Lianyungang,Jiangsu 222000,China)

机构地区：[1]锦州医科大学,辽宁锦州121001 [2]南京医科大学连云港临床医学院,江苏连云港222000 [3]徐州医科大学附属连云港医院麻醉科,江苏连云港222000 [4]南京医科大学康达学院第一附属医院麻醉科,江苏连云港222000

出　　处：《现代医药卫生》2024年第12期2087-2093,共7页Journal of Modern Medicine & Health

基　　金：国家自然科学基金项目(81970348);江苏省六大人才高峰项目(WSW-329);连云港市第一人民医院临床研究基金项目(LC13)。

摘　　要：镁是人体中第二丰富的阳离子,在机体的多种生理过程中都发挥着重要作用,硫酸镁作为镁的药理形式,是一种天然的N-甲基-D-天冬氨酸受体阻滞剂及钙通道阻滞剂。早先研究发现它可以用于防治子痫前期患者癫痫发作,还被用于治疗心律失常和哮喘等疾病。随着研究不断深入,其在围手术期麻醉过程中的作用也愈益突出。它能够对麻醉药物产生协同作用,减少麻醉药物的使用,还具有抗炎、抑制应激反应、维持循环稳定及神经保护的作用。应用硫酸镁的方式不同可能产生不同的效果,本文就硫酸镁在围手术期麻醉过程中的不同实践进行综述。Magnesium is the second most abundant cation in the human body and plays an important role in various physiological processes of the body.Magnesium sulfate,as a pharmacological form of magnesium,is a natural N-methyl-D-aspartate receptor blocker and calcium channel blocker.Previous studies have found that it can be used to prevent seizures inpatients with preeclamptic,and is also used to treat diseases such as arrhythmias and asthma.With the deepening of research,its role in perioperative anesthesia is becoming more and more prominent.It can have a synergistic effect on anesthetic drugs,reduce the use of anesthetic drugs,and also has anti-inflammatory,inhibiting stress response,maintaining circulatory stabilizing and neuroprotective effects.Different ways of applying magnesium sulfate may produce different effects.This article reviews the different practices of magnesium sulfate in the perioperative anesthesia process.

关 键 词：硫酸镁 麻醉 围手术期 镇痛 综述 

分 类 号：R614[医药卫生—麻醉学]