热休克蛋白70在肺癌侵袭和转移中的研究进展  

Research progress of heat shock proteins 70 in invasion and metastasis of lung cancer

作　　者：刘鑫(综述)[1] 乔晓娟[2] 呼群(审校)[2] LIU Xin;QIAO Xiaojuan;HU Qun(Inner Mongolia Medical University,Hohhot,Inner Mongolia 010059,China;Department of Oncology,the Affiliated Hospital of Inner Mongolia Medical University,Hohhot,Inner Mongolia 010059,China)

机构地区：[1]内蒙古医科大学,内蒙古呼和浩特010059 [2]内蒙古医科大学附属医院肿瘤内科,内蒙古呼和浩特010059

出　　处：《现代医药卫生》2024年第12期2131-2135,共5页Journal of Modern Medicine & Health

基　　金：内蒙古自治区自然科学基金项目(2021LHMS08046;2021MS08153)。

摘　　要：肺癌是一种对人类身心造成严重危害的疾病,是全球的重大公共卫生问题。目前,尽管靶向药物、化疗药物及免疫药物的联合使用使肺癌患者的生存期和生活质量得到提升,但复发和远处转移的发生意味着肺癌治疗面临新的困难。热休克蛋白70(Hsp70)作为一种在进化上高度保守的分子伴侣,在包括肺癌在内的多种实体肿瘤细胞中高表达,通过抑制细胞凋亡、促进肿瘤微环境的形成、诱导上皮间充质转化及维持癌症干细胞的干细胞特性,促进肺癌的侵袭及转移,因此通过研究Hsp70在肺癌侵袭及远处转移中的相关机制,寻找治疗肺癌的新靶点,并与目前的常规治疗结合,可能为肺癌的治疗提供新的治疗策略,该文就以上方面进行综述。Lung cancer is a disease that causes serious harm to human body and mind.It is a major public health problem worldwide.At present,although the combination of targeted drugs,chemotherapy drugs and immune drugs has improved the survival and quality of life of patients,the occurrence of recurrence and distant metastasis means that lung cancer treatment faces new difficulties.As an evolutionarily highly conserved chaperone,Heat-Shock Protein 70(Hsp70)is highly expressed in cells in a variety of solid tumors,including lung cancer,and promotes lung cancer invasion and metastasis by inhibiting apoptosis,promoting the formation of tumor microenvironment,inducing epithelial mesenchymal transformation,and maintaining the stem cell properties of cancer stem cells.Therefore,by studying the relevant mechanism of Hsp70 in lung cancer invasion and distant metastasis,finding new targets for the treatment of lung cancer,and combining it with the current conventional treatment,it may provide new treatment strategies for the treatment of lung cancer.This article reviews the above aspects.

关 键 词：热休克蛋白70 肺癌 耐药性 转移 综述 

分 类 号：R563.9[医药卫生—呼吸系统]