间质性肺疾病合并结核分枝杆菌感染的研究进展  

Research progress on interstitial lung disease combined with Mycobacterium tuberculosis infection

作　　者：傅可言 朱邦政 叶健 Fu Keyan;Zhu Bangzheng;Ye Jian(Zhejiang Chinese Medical University,Hangzhou 310053,China;Department of Respiratory Medicine,Zhejiang Hospital,Hangzhou 310013,China)

机构地区：[1]浙江中医药大学,杭州310053 [2]浙江医院呼吸内科,杭州310013

出　　处：《中国防痨杂志》2024年第7期823-829,共7页Chinese Journal of Antituberculosis

基　　金：浙江省医药卫生科技计划项目(2022KY952)。

摘　　要：在呼吸系统疾病中,间质性肺疾病和肺结核为两种常见且可对健康造成不同程度危害的疾病。肺结核是一种由结核分枝杆菌引起的传染性疾病,在全球范围内造成严重的疾病负担。间质性肺疾病是一组以慢性炎症和肺泡间质纤维化为特征的非传染性肺部疾病,同样对患者的生活质量和预后产生深远影响。肺部间质性及纤维化改变可能会掩盖感染的征象,而结核分枝杆菌感染会进一步加重间质性肺疾病病情。因此,当肺结核与间质性肺疾病合并发生时,它们的相互作用及共存使得及时诊治存在挑战性,同时也影响疾病的预后和转归。本文对间质性肺疾病合并结核分枝杆菌感染的流行病学、发生机制、诊断方法、高危因素,以及治疗等方面的研究进展进行综述,以期为临床诊治提供参考。Interstitial lung disease(ILD)and pulmonary tuberculosis(TB)are two prevalent respiratory diseases that can significantly impact health.TB,caused by Mycobacterium tuberculosis,is an infectious disease imposing a severe disease burden globally.In contrast,ILD is a group of non-communicable lung diseases characterized by chronic inflammation and alveolar interstitial fibrosis,profoundly affecting patients’quality of life and prognosis.The interstitial and fibrotic changes in the lungs can mask signs of infection,while Mycobacterium tuberculosis infection can further worsen the condition of ILD.Therefore,when TB and ILD coexist,their interaction complicates timely diagnosis and treatment,adversely affecting the disease prognosis and outcome.This review summarizes the research progress in the epidemiology,pathogenesis,diagnostic methods,high-risk factors,and treatment of ILD combined with Mycobacterium tuberculosis infection,aiming to provide references for clinical diagnosis and treatment.

关 键 词：肺疾病 间质性 分枝杆菌 结核 感染 共病现象 总结性报告(主题) 

分 类 号：R563[医药卫生—呼吸系统] R52[医药卫生—内科学]