G蛋白偶联受体在宿主抗结核分枝杆菌感染中的功能及作用机制  

The function and mechanism of G protein-coupled receptors in host against Mycobacterium tuberculosis infection

作　　者：刘浩瀚 马子淳 逄宇 李姗姗 Liu Haohan;Ma Zichun;Pang Yu;Li Shanshan(Department of Bacterial Immunology,Beijing Chest Hospital,Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute/Beijing Key Laboratory of Drug-resistant Tuberculosis Research,Beijing 101149,China)

机构地区：[1]首都医科大学附属北京胸科医院/北京市结核病胸部肿瘤研究所细菌免疫学实验室/耐药结核病研究北京市重点实验室,北京101149

出　　处：《中国防痨杂志》2024年第7期839-844,共6页Chinese Journal of Antituberculosis

基　　金：国家自然科学基金(82202530)。

摘　　要：G蛋白偶联受体(GPCRs)在维持人体正常生理功能和细胞内稳态过程中发挥关键作用。GPCRs及其下游信号通路的表达失调是疾病发生发展的重要标志。近年来,结核病的防治面临着更加严峻的挑战,亟需研发安全、价廉、敏感的新型抗结核药物。其中,基于宿主导向治疗策略的新型抗菌药物受到广泛关注,而GPCRs作为宿主发挥免疫表达调控作用的受体之一,可作为宿主导向的抗结核潜在治疗靶标,然而GPCRs作为重要的药物研究靶点在结核病领域的研究尚显不足。笔者总结了近年来发现的GPCRs在宿主细胞应答结核分枝杆菌感染中所发挥的功能,系统综述了趋化因子受体类GPCRs、孤儿GPCRs及其他GPCRs在调控宿主细胞信号转导中发挥的关键作用和分子机制,为基于GPCRs的抗结核药物研发提供依据。G protein-coupled receptors(GPCRs)play a critical role in maintaining normal physiological functions and intracellular homeostasis in the human body.Dysregulation of GPCRs and their downstream signaling pathways are significant markers in the development and progression of various diseases.In recent years,the prevention and treatment of tuberculosis(TB)have faced increasingly severe challenges,highlighting the urgent need for the development of new anti-TB drugs that are safe,affordable,and sensitive.Among these,novel antimicrobial drugs based on host-directed therapeutic strategies have garnered widespread attention.GPCRs,as receptors that regulate host immune expression,can serve as potential therapeutic targets for host-directed anti-TB treatment.However,researches on GPCRs as important drug targets in the field of TB are still insufficient.The author summarizes the recently discovered functions of GPCRs in host cell responses to Mycobacterium tuberculosis infection.It systematically reviews the key roles and molecular mechanisms of chemokine receptor-like GPCRs,orphan GPCRs,and other GPCRs in regulating host cell signal transduction,providing a basis for the development of GPCR-based anti-TB drugs.

关 键 词：受体 G-蛋白偶联 巨噬细胞 分枝杆菌 结核 感染 

分 类 号：R373.5[医药卫生—病原生物学] R392[医药卫生—基础医学]