血清SOCS-1、SOCS-3及抗BP-180抗体水平与大疱性类天疱疮病情的相关分析  

Correlation Analysis of Serum SOCS-1,SOCS-3 and Anti-BP-180 Antibody Levels with Bullous Pemphigoid Disease

作　　者：李丙南 刘桂丽 赵子申 张海祥 秦兰英 

机构地区：[1]河北省沧州市人民医院,河北沧州061000

出　　处：《中国中西医结合皮肤性病学杂志》2024年第3期197-201,共5页Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine

基　　金：2021年河北省医学科学研究项目(编号:20211626)。

摘　　要：目的探讨血清细胞因子信号转导抑制蛋白-1(SOCS-1)、SOCS-3及抗大疱性类天疱疮(BP)-180抗体水平与BP病情的相关分析。方法选取2018年5月—2022年5月本院诊治的82例BP患者作为研究对象,并将其设立为观察组,同期选取41例健康体检者作为对照组,并根据病情程度将82例BP患者分为轻度组(活动性皮损面积≤10%,n=28)、中度组(活动性皮损面积10%~30%,n=27)和重度组(活动性皮损面积>30%,n=27),展开回顾性研究,对比血清SOCS-1、SOCS-3、抗BP-180抗体水平及自身免疫性大疱性皮肤病严重程度评分(ABSIS);采用Pearson法分析SOCS-1、SOCS-3、抗BP-180抗体与ABSIS评分的相关性;并绘制受试者工作特征(ROC)曲线评估SOCS-1、SOCS-3、抗BP-180抗体诊断BP的曲线下面积(AUC)、敏感度和特异度。结果观察组的男性、女性均可发病,性别分布上差异无统计学意义,其中40~69岁为高发的年龄段。观察组的SOCS-1、SOCS-3、抗BP-180抗体及ABSIS均高于对照组(P<0.05)。重度组的SOCS-1、SOCS-3、抗BP-180抗体及ABSIS均高于轻度组和中度组(P<0.05);中度组的SOCS-1、SOCS-3、抗BP-180抗体及ABSIS均高于轻度组(P<0.05)。Pearson相关性分析显示,SOCS-1、SOCS-3、抗BP-180抗体与ABSIS呈正相关(r分别为0.441、0.580、0.723,P<0.001)。ROC曲线分析显示,SOCS-1、SOCS-3和抗BP-180抗体诊断BP的AUC值分别为0.696、0.765和0.965(P<0.05);敏感度分别为53.70%、41.50%和95.10%,特异度分别为87.80%、100.00%和85.40%。结论血清SOCS-1、SOCS-3及抗BP-180抗体水平与BP病情严重程度呈正相关,即其水平会随着病情程度变化而发生改变,临床可通过监测SOCS-1、SOCS-3及抗BP-180抗体水平变化为诊断BP及评估病情严重程度提供参考。Objective In order to investigate the correlation between serum levels of suppressor of cytokine signaling-1(SOCS-1),SOCS-3 and anti-bullous pemphigoid(BP)-180 antibody and BP disease.Methods A total of 82 patients with BP diagnosed and treated from May 2018 to May 2022 were selected and set as the observation group,41 healthy subjects were selected as the control group.According to the severity of the disease,82 patients with BP were divided into the mild group(the area of active lesions≤10%,n=28),moderate group(active skin lesion area 10%-30%,n=27),severe group(active skin lesion area>30%,n=27).The serum levels of SOCS-1,SOCS-3,anti-BP-180 antibody and autoimmune bullous skin disease severity score(ABSIS)were compared.Pearson method was used to analyze the correlation among SOCS-1,SOCS-3,anti-BP-180 antibody and ABSIS score.The receiver operating characteristic(ROC)curve was drawn to evaluate the area under the curve(AUC),sensitivity and specificity of SOCS-1,SOCS-3 and anti-BP-180 antibodies in the diagnosis of BP.Results Both males and females in the observation group were affected,and there were no significant differences in gender distribution,with the age range from 40 to 69 years old being the highest incidence.The SOCS-1,SOCS-3,anti-BP-180 antibody and ABSIS scores in the observation group were higher than those in the control group(P<0.05).The scores of SOCS-1,SOCS-3,anti-BP-180 antibody and ABSIS in severe group were higher than those in mild and moderate groups(P<0.05).The scores of SOCS-1,SOCS-3,anti-BP-180 antibody and ABSIS in moderate group were higher than those in mild group(P<0.05).Pearson correlation analysis showed that SOCS-1,SOCS-3 and anti-BP180 antibody were positively correlated with ABSIS score(r=0.441,0.580,0.723,P<0.001).ROC curve analysis showed that the AUC values of SOCS-1,SOCS-3 and anti-BP180 antibody in the diagnosis of BP were 0.696,0.765 and 0.965,respectively(P<0.05).The sensitivities were 53.70%,41.50%and 95.10%,respectively.The specificity were 87.80%,100.00%and 85.40%,re

关 键 词：细胞因子信号转导抑制蛋白-1 细胞因子信号转导抑制蛋白-3 抗BP-180抗体 大疱性类天疱疮 

分 类 号：R758.66[医药卫生—皮肤病学与性病学]