重组人血小板生成素联合环孢素治疗再生障碍性贫血患儿的效果  

Effects of recombinant human thrombopoietin combined with Cyclosporine in treatment of children with aplastic anemia

作　　者：周莹莹 黄蓉 南慧 ZHOU Yingying;HUANG Rong;NAN Hui(Department of Pediatrics of Shangqiu First People’s Hospital,Shangqiu 476000 Henan,China)

机构地区：[1]商丘市第一人民医院儿科,河南商丘476000

出　　处：《中国民康医学》2024年第12期65-68,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察重组人血小板生成素联合环孢素治疗再生障碍性贫血(AA)患儿的效果。方法:回顾性分析2020年1月至2023年4月该院收治的60例AA患儿的临床资料,按照治疗方法不同将其分为对照组和观察组各30例。对照组予以环孢素治疗,观察组在对照组基础上联合重组人血小板生成素治疗。比较两组临床疗效,血小板计数(PLT)恢复时间,临床指标(骨髓巨核细胞个数、血小板输注量、粒细胞恢复时间)水平,治疗前后血管内皮生长因子-C(VEGF-C)水平、氧化应激指标[还原型谷胱甘肽(GSH)、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、丙二醛(MDA)]水平,以及不良反应发生率。结果:观察组治疗总有效率为96.67%(29/30),高于对照组的66.67%(20/30),差异有统计学意义(P<0.05);两组PLT≥20×10^(9)/L恢复时间比较,差异无统计学意义(P>0.05);观察组PLT≥50×10^(9)/L、PLT≥100×10^(9)/L恢复时间均短于对照组,差异有统计学意义(P<0.05);观察组骨髓巨核细胞计数高于对照组,血小板输注量少于对照组,粒细胞恢复时间短于对照组,差异均有统计学意义(P<0.05);治疗后,观察组VEGF-C水平高于对照组,差异有统计学意义(P<0.05);治疗后,观察组MDA水平低于对照组,CAT、GSH、SOD水平高于对照组,差异均有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:重组人血小板生成素联合环孢素治疗AA患儿可提高治疗总有效率和VEGF-C水平,缩短PLT恢复时间,改善临床指标、氧化应激指标水平,效果优于单纯环孢素治疗。Objective:To observe effects of recombinant human thrombopoietin combined with Cyclosporine in treatment of children with aplastic anemia(AA).Methods:The clinical data of 60 children with AA admitted to this hospital from January 2020 to April 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,30 cases in each group.The control group was treated with Cyclosporine,while the observation group was treated with recombinant human thrombopoietin on the basis of that of the control group.The clinical efficacy,the platelet count(PLT)recovery time,the clinical indicators(bone marrow megakaryocyte count,platelet transfusion volume,granulocyte implantation time)levels,the vascular endothelial growth factor-C(VEGF-C)levels,the oxidative stress indicators[reduced glutathione(GSH),superoxide dismutase(SOD),catalase(CAT),malondialdehyde(MDA)]levels,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of the observation group was 96.67%(29/30),which was higher than 66.67%(20/30)of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the recovery time of PLT≥20×10^(9)/L between two groups(P>0.05).The recovery time of PLT≥50×10^(9)/L and PLT≥100×10^(9)/L in the observation group was shorter than that in the control group,and the difference was statistically significant(P<0.05).The bone marrow megakaryocyte count in the observation group was higher than that in the control group,the platelet transfusion volume was less than that in the control group,the granulocyte implantation time was shorter than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the level of VEGF-C in the observation group was higher than that in the control group,the difference was statistically significant(P<0.05).After the treatment,the level of MDA in th

关 键 词：再生障碍性贫血 重组人血小板生成素 环孢素 血小板恢复时间 氧化应激 血管内皮生长因子-C 

分 类 号：R556.5[医药卫生—血液循环系统疾病]