葡萄糖酸钙锌联合维生素D治疗维生素D缺乏性佝偻病患儿的效果  

Effects of Calcium and zinc gluconate combined with Vitamin D in treatment of children with Vitamin D deficiency rickets

作　　者：王玉华 郑焕珍 段红云 WANG Yuhua;ZHENG Huanzhen;DUAN Hongyun(Department of Pediatrics of Jinshui District General Hospital,Zhengzhou 450000 Henan,China;Department of Pediatrics of Zhengzhou People’s Hospital,Zhengzhou 450000 Henan,China)

机构地区：[1]郑州市金水区总医院儿科,河南郑州450000 [2]郑州人民医院儿科,河南郑州450000

出　　处：《中国民康医学》2024年第12期76-78,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察葡萄糖酸钙锌联合维生素D治疗维生素D缺乏性佝偻病患儿的效果。方法:选取2021年4月至2023年3月郑州市金水区总医院收治的72例维生素D缺乏性佝偻病患儿进行前瞻性研究,按照随机数字表法分为观察组与对照组各36例。对照组采用维生素D治疗,观察组在对照组基础上联合葡萄糖酸钙锌治疗,比较两组生长指标{血清骨碱性磷酸酶(BALP)、血清25-羟维生素D3[25-(OH)D3]、身高}水平、骨代谢指标[血清硬骨素(SOST)、抗酒石酸酸性磷酸酶5b(TRAP-5b)、Ⅰ型胶原交联羧基端肽(CTX-Ⅰ)、成纤维细胞生长因子23(FGF23)、粒细胞集落刺激因子(G-CSF)]和不良反应发生率。结果:治疗3、6个月后,观察组身高及25-(OH)D3、SOST、TRAP-5b、CTX-Ⅰ水平高于对照组,BALP、FGF-23、G-CSF水平低于对照组,差异均有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:葡萄糖酸钙锌联合维生素D治疗维生素D缺乏性佝偻病患儿可改善其生长指标和骨代谢指标水平,效果优于单纯维生素D治疗。Objective:To observe effects of Calcium and zinc gluconate combined with Vitamin D in treatment of children with Vitamin D deficiency rickets.Methods:A prospective study was conducted on 72 children with Vitamin D deficiency rickets admitted to Jinshui District General Hospital from April 2021 to March 2023.According to the random number table method,they were divided into observation group and control group,36 cases in each group.The control group was treated with Vitamin D,while the observation group was treated with Calcium and zinc gluconate on the basis of that of the control group.The levels of growth indicators[serum bone alkaline phosphatase(BALP),serum 25-hydroxyVitamin D3[25-(OH)D3],height]levels,the bone metabolism indicators[serum sclerostin(SOST),tartrate-resistant acid phosphatase 5b(TRAP-5b),type I collagen cross-linked carboxy-terminal peptide(CTX-I),fibroblast growth factor 23(FGF23),granulocyte colony-stimulating factor(G-CSF)]levels,and the incidence of adverse reactions were compared between the two groups.Results:After 3 and 6 months of treatment,height and the levels of 25-(OH)D3,SOST,TRAP-5 b and CTX-I in the observation group were higher than those in the control group;the levels of BALP,FGF-23 and G-CSF were lower than those in the control group;and the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Calcium and zinc gluconate combined with Vitamin D can improve the levels of growth indexes and bone metabolism indicators in the children with Vitamin D deficiency rickets.Moreover,it is superior to single Vitamin D treatment.

关 键 词：葡萄糖酸钙锌 维生素D 维生素D缺乏性佝偻病 生长 骨代谢 不良反应 

分 类 号：R681[医药卫生—骨科学]