清肺消痈汤联合纤维镜肺泡灌洗术治疗肺脓肿患者的效果  

Effects of Qingfei Xiaoyong decoction combined with fibroscopic alveolar lavage in treatment of pulmonary abscess

作　　者：樊佳 FAN Jia(Department of Respiratory and Critical Care Medicine of Zhengzhou People’s Hospital(East Hospital),Zhengzhou 450000 Henan,China)

机构地区：[1]郑州人民医院(东院区)呼吸与危重症医学科,河南郑州450000

出　　处：《中国民康医学》2024年第12期92-95,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察清肺消痈汤联合纤维镜肺泡灌洗术治疗肺脓肿患者的效果。方法:回顾性分析2021年4月至2023年4月该院收治的86例肺脓肿患者的临床资料,根据治疗方法不同将其分为对照组和研究组各43例。对照组给予纤维镜肺泡灌洗术治疗,研究组在对照组基础上联合清肺消痈汤治疗。比较两组临床疗效、治疗前后中医证候积分、血气分析指标[动脉血氧分压(PaO_(2))、动脉血氧饱和度(SaO_(2))、氧合指数(PaO_(2)/FiO_(2))]水平、炎性因子[单核细胞趋化蛋白1(MCP-1)、肿瘤坏死因子-α(TNF-α)、肺表面活性蛋白A(SPA)、高迁移率蛋白1(HMGB1)]水平及不良反应发生率。结果:研究组治疗总有效率为95.35%(41/43),高于对照组的79.07%(34/43),差异有统计学意义(P<0.05);治疗后,两组咳嗽、浊痰腥臭、胸痛、高热等中医证候积分均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组PaO_(2)、SaO_(2)、PaO_(2)/FiO_(2)水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);两组MCP-1、TNF-α、SPA、HMGB1水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:清肺消痈汤联合纤维镜肺泡灌洗术治疗肺脓肿患者,可提高临床疗效,降低中医证候积分,改善血气分析指标水平,减轻机体炎症反应,效果优于单纯纤维镜肺泡灌洗术治疗。Objective:To observe effects of Qingfei Xiaoyong decoction combined with fibroscopic alveolar lavage in treatment of pulmonary abscess.Methods:The clinical data of 86 patients with pulmonary abscess in this hospital from April 2021 to April 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group and study group,43 cases in each group.The control group was treated withfibroscopic alveolar lavage,while the study group was treated with Qingfei Xiaoyong decoction on the basis of that of the control group.The clinical efficacy,the TCM syndrome scores before and after the treatment,the blood gas analysis indexes[arterial partial pressure of oxygen(PaO_(2)),blood oxygen saturation(SaO_(2)),oxygenation index(PaO_(2)/FiO_(2))]levels,the inflammatory factors[monocyte chemoattractant protein-1(MCP-1),tumor necrosis factor-α(TNF-α),pulmonary surfactant protein A(SPA),high mobility protein 1(HMGB1)]levels,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was 95.35%(41/43),which was higher than 79.07%(34/43)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the scores of TCM syndromes such as cough,turbid phlegm,chest pain and high fever in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of PaO_(2),SaO_(2)and PaO_(2)/FiO_(2)in the two groups were higher than those before the treatment,those in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of MCP-1,TNF-α,SPA and HMGB1 in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the in

关 键 词：清肺消痈汤 纤维镜肺泡灌洗术 肺脓肿 中医证候积分 炎性因子 血氧饱和度 氧合指数 

分 类 号：R246.1[医药卫生—针灸推拿学]