血清SDC-1、HDAC6、CC16水平联合检测对慢性阻塞性肺疾病患者预后不良的预测价值  

Predictive value of combined detection of serum SDC-1, HDAC6 and CC16 levels for poor prognosis in patients with chronic obstructive pulmonary disease

作　　者：王志刚[1] 武静[1] 王嘉琳 WANG Zhigang;WU Jing;WANG Jialin(Department of Respiratory Medicine of the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000 Henan,China)

机构地区：[1]郑州大学第一附属医院呼吸内科,河南郑州450000

出　　处：《中国民康医学》2024年第12期134-136,140,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:探讨血清多配体蛋白聚糖1(SDC-1)、组蛋白去乙酰化酶6(HDAC6)、克拉拉细胞分泌蛋白16(CC16)水平联合检测对慢性阻塞性肺疾病(COPD)患者预后不良的预测价值。方法:选取2020年11月至2023年11月该院收治的147例COPD患者进行横断面研究,设为研究组;选取同期于该院体检的147名健康者设为对照组。比较两组、不同COPD病情程度患者、不同预后COPD患者血清SDC-1、HDAC6、CC16水平;采用受试者工作特征(ROC)曲线分析入院时血清SDC-1、HDAC6、CC16水平单项及联合检测预测COPD患者预后不良的价值。结果:研究组血清SDC-1、HDAC6水平均高于对照组,血清CC16水平低于对照组,差异有统计学意义(P<0.05)。重度COPD患者血清SDC-1、HDAC6水平高于中重度、中度、轻度患者,且中重度高于中度、轻度患者,中度高于轻度患者;重度COPD患者血清CC16水平低于中重度、中度、轻度患者,且中重度低于中度、轻度患者,中度低于轻度患者,差异均有统计学意义(P<0.05)。预后不良COPD患者入院时血清SDC-1、HDAC6水平高于预后良好患者,血清CC16水平低于预后良好患者,差异均有统计学意义(P<0.05)。ROC曲线分析结果显示,入院时血清SDC-1、HDAC6、CC16水平联合检测预测COPD患者预后不良的曲线下面积(AUC)为0.938,高于三者单项检测诊断(AUC=0.774、0.771、0.716)。结论:入院时血清SDC-1、HDAC6、CC16水平联合检测预测COPD患者预后不良的价值高于三者单项检测。Objective:To investigate predictive value of combined detection of serum multiligand proteoglycan 1(SDC-1),histone deacetylase 6(HDAC6)and Clara cell secretory protein 16(CC16)levels for poor prognosis in patients with chronic obstructive pulmonary disease(COPD).Methods:A cross-sectional study was conducted on 147 patients with COPD admitted to the hospital from November 2020 to November 2023,and they were set as the study group.147 healthy people who underwent physical examination in the hospital during the same period were selected and they were set as the control group.The serum levels of SDC-1,HDAC6 and CC16 were compared between the two groups and among the patients with different severity of COPD and the patients with different prognosis of COPD.The receiver operating characteristic(ROC)curve was used to analyze the value of single and combined detection of serum SDC-1,HDAC6 and CC16 levels at admission in the prediction of poor prognosis of the COPD patients.Results:The levels of serum SDC-1 and HDAC6 in the study group were higher than those in the control group,the level of serum CC16 was lower than that in the control group,and the differences were statistically significant(P<0.05).The levels of serum SDC-1 and HDAC6 in the patients with severe COPD were higher than those in the patients with moderate to severe,moderate and mild COPD,those in the patients with moderate to severe COPD were higher than those in the patients with moderate and mild COPD,and those in the patients with moderate COPD were higher than those in the patients with mild COPD;the serum CC16 level in the patients with severe COPD was lower than that in the patients with moderate to severe,moderate and mild COPD,that in the patients with moderate to severe COPD was lower than that in the patients with moderate and mild COPD,and that in the patients with moderate COPD was lower than that in the patients with mild COPD;and the differences were statistically significant(P<0.05).The levels of serum SDC-1 and HDAC6 at admission in the pati

关 键 词：多配体蛋白聚糖1 组蛋白去乙酰化酶6 克拉拉细胞分泌蛋白16 检测 慢性阻塞性肺疾病 

分 类 号：R714.253[医药卫生—妇产科学]