口罩伴侣清凉提神水凝胶贴片的制备工艺研究  

Study on Preparation of Mask Mate Cool Refreshing Hydrogel Patch

作　　者：李若涵 汪千千 张艳焱 徐剑 Li Ruohan;Wang Qianqian;Zhang Yanyan;Xu Jian(College of Pharmacy,Guizhou University of Traditional Chinese Medicine,Guiyang 550025,China)

机构地区：[1]贵州中医药大学药学院,贵州贵阳550025

出　　处：《云南化工》2024年第6期39-44,共6页Yunnan Chemical Technology

基　　金：贵州中医药大学大学生创新创业训练计划项目(贵中医大创合字(2022)107号)。

摘　　要：(目的)制备一款载薄荷油的凝胶贴片,贴附于口罩内壁,对口罩佩戴时间过久产生的心情烦闷、精神疲倦、有臭气等问题进行优化。(方法)以聚乙烯醇(PVA)和壳聚糖(CS)为原料,采用循环冷冻/解冻法制备薄荷油/PVA/CS复合水凝胶贴片,在单因素试验基础上以响应面法优化出最佳制备工艺,并采用单盲法测试出薄荷油最佳载药量。(结果)水凝胶贴片的最佳制备工艺条件为:PVA溶液与CS溶液质量比5.3∶1、冷冻时长12.5 h、冷冻次数4次,载薄荷油量0.5%~0.6%。(结论)运用响应面法制备得到的水凝胶贴片具有黏性好、使用方便、体积较小、芳香气味持续时间久、安全无毒、无刺激等优点,表明优化水载薄荷油的凝胶贴片的制备工艺合理、可行。(Objective)To prepare an oil of peppermint gel patch,which is attached to the inner wall of a mask,to optimize the mask wearing for prolonged wear,such as boredom,mental fatigue,stench.(Methods)The raw materials are polyvinyl alcohol(PVA)and chitosan(CS).The oil of peppermint/PVA/CS composite hydrogel patch is prepared by cyclic freezing/thawing method.The optimum preparation process is optimized by RSM,and the optimum drug loading of the oil of peppermint is determined by single blind method.(Results)The optimal preparation conditions are as follows:PVA/CS ratio 5.3∶1,freezing time 12.5 h,freezing times 4 times,oil of peppermint 0.5%~0.6%.(Conclusion)The hydrogel patch prepared by RSM has the advantages of good viscosity,easy to use,small size,long lasting fragrance,safe,non-toxic,non-irritant and so on.It is reasonable and feasible to optimize the preparation process of oil of peppermint.

关 键 词：水凝胶贴片 单因素试验 响应面优化 单盲法 

分 类 号：R283[医药卫生—中药学]