动态单光子发射计算机断层成像检测异常灌注面积与冠状动脉严重程度的相关性分析  

Analysis on correlation between abnormal perfusion area detected by single-photon emission computed tomography system and coronary artery severity degree

作　　者：李柳[1] 郑庆厚[1] 高歌 李晓燕[1] 陈勤聪 王硕 LI Liu;ZHENG Qinghou;GAO Ge;LI Xiaoyan;CHEN Qincong;WANG Shuo(Department of Cardiology,First Hospital of Hebei Medical University,Shijiazhuang,Hebei 050011,China;Department of Cardiology,Shijiazhuang Municipal People’s Hospital,Shijiazhuang,Hebei 050031,China)

机构地区：[1]河北医科大学第一医院心内科,石家庄050011 [2]石家庄市人民医院心内科,石家庄050031

出　　处：《重庆医学》2024年第12期1793-1797,共5页Chongqing medicine

基　　金：河北省中医药管理局科研计划项目(2023322)。

摘　　要：目的研究静息+瑞加诺生负荷动态单光子发射计算机断层成像(D-SPECT)检测的异常灌注面积与冠状动脉病变严重程度的相关性。方法选取2022年4月1日至2023年4月1日在河北医科大学第一医院心内科住院,需行冠状动脉造影及经皮冠状动脉介入(PCI)的患者100例作为研究对象,采用心脏专用机D-SPECT行静息+瑞加诺生负荷检测。按照瑞加诺生负荷D-SPECT时较静息检查时出现心肌节段性放射核素分布稀疏或者缺损的范围占比,将患者分为轻度缺血组(范围<10%)、中度缺血组(范围为10%~20%)、重度缺血组(范围>20%),并行冠状动脉造影检查,计算Gensini评分。结果重度缺血组患者Gensini评分为(55.70±20.60)分,高于中度缺血组的(41.88±28.07)分和轻度缺血组的(39.71±21.40)分,差异有统计学意义(P<0.05);轻度缺血组和中度缺血组Gensini评分比较,差异无统计学意义(P>0.05)。重度缺血组的平均支架长度为(30.50±7.47)mm,高于轻度缺血组的(20.90±4.72)mm和中度缺血组的(23.50±3.87)mm,差异有统计学意义(P<0.05),轻度缺血组和中度缺血组平均支架长度比较,差异无统计学意义(P>0.05)。结论应用静息+瑞加诺生负荷D-SPECT检测的异常灌注面积有助于评估冠状动脉病变严重程度及需植入支架长度。Objective To study the correlation between the abnormal perfusion area detected by resting+regadenoson stress D-SPECT and the severity of coronary arterial lesions.Methods One hundred patients needing coronary angiography and PCI admitted in the cardiology department of First Hospital of Hebei Medical University from April 1,2022 to April 1,2023 were selected as the study subjects.The resting+regadenoson loading examination was performed by using the special cardiac machine D-SPECT.The patients were divided into the mild ischemia group(range<10%),moderate ischemia group(range 10%-20%)and severe ischemia group(range>20%)according to the proportion of sparse or defect appearance in myocardial segmental radionuclide distribution during regadenoson stress D-SPECT in comparison with resting examination.The coronary arterial angiography was performed.The Gensini score was calculated.Results The Gensini score in the severe ischemia group was(55.70±20.60)points,which was higher than(41.88±28.07)points in the moderate ischemia group and(39.71±21.40)points in the mild ischemia group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the Gensini score between the mild ischemia group and moderate ischemia group(P>0.05).The mean stent length in the severe ischemia group was(30.50±7.47)mm,which was significantly higher than(20.90±4.72)mm in the mild ischemia group and(23.50±3.87)mm in the mo derate ischemia group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the mean stent length between the mild ischemia group and moderate ischemia group(P>0.05).Conclusion The abnormal perfusion area detected by resting+regadenoson stress D-SPECT is conducive to evaluate the severity of coronary arterial lesions and the length of needing implantation stent.

关 键 词：瑞加诺生 动态单光子发射计算机断层成像 GENSINI评分 支架长度 冠状动脉 

分 类 号：R541.4[医药卫生—心血管疾病]