糖尿病肾脏疾病患者可溶性α-Klotho水平与持续血糖监测中血糖控制相关性的研究  

Correlation between soluble α-Klotho levels with diabetic kidney disease and blood glucose control during continuous blood glucose monitoring

作　　者：李林娟[1] 郑俊晨[2] 张梅[1] 王瑞 杨宁[3] LI Linjuan;ZHENG Junchen;ZHANG Mei;YANG Ning(Department of General Medicine,Yan'an University Affiliated Hospital,Yan'an 716000,China)

机构地区：[1]延安大学附属医院全科医学科,716000 [2]延安大学附属医院心血管病中心,716000 [3]延安大学附属医院呼吸内科,716000

出　　处：《中国糖尿病杂志》2024年第5期343-346,共4页Chinese Journal of Diabetes

基　　金：陕西省自然科学基金(2022JM-471);延安大学附属医院科学技术研究发展计划项目(2021PT-03)。

摘　　要：目的 探讨DKD患者可溶性α-Klotho(SKL)水平与持续血糖监测(CGMS)中血糖控制的相关性。方法 选取2020年5月至2022年5月于延安大学附属医院全科医学科治疗的T2DM患者140例,根据UACR水平分为单纯T2DM组(UACR<30 mg/g,n=60)和合并DKD组(DKD,UACR≥30 mg/g,n=80),同期选取45名体检健康者为正常对照(NC)组。结果 DKD组SKL低于T2DM、NC组(P<0.05)。Spearman相关分析显示,SKL与eGRF及TIR呈正相关(P<0.01),与FPG、HbA_(1)c、血肌酐、UACR、胱抑素C、β2微球蛋白、平均血糖、血糖高于目标范围时间及血糖管理指标(GMI)呈负相关(P<0.01)。多元线性回归分析显示,HbA_(1)c、GMI是SKL的影响因素。结论 DKD患者SKL水平与HbA_(1)c及GMI相关。Objective To analyze the relationship between soluble α-Klotho(SKL) levels and continuous glucose monitoring(CGMS)-derived measures of glycemic management in diabetic kidney disease(DKD)patients.Methods A total of 140 T2DM patients admitted to the Department of General Medicine Affiliated Hospital of Yan'an University from May 2020 to May 2022 were selected and divided into two groups according to the levels of UACR:T2DM group(UACR<30 mg/g,n=60),DKD group(UACR≥30 mg/g,n=80) and 45 healthy persons(NC group) who received physical examination in the hospital during the same period were the NC group.Results The SKL level of DKD group was lower than that of T2DM group and NC group(P<0.05).Spearman correlation analysis showed that SKL was positively correlated with eGRF and TIR(P<0.01),and negatively correlated with Scr,UACR,Cys C,β2-MG,FPG,HbA_1c,MG,TAR and GMI(P<0.01).Multiple linear regression analysis showed that HbA_(1c) and GMI were the influencing factors of SKL.Conclusion The level of SKL in DKD patients is correlated with HbA1c and GMI.

关 键 词：糖尿病肾脏疾病 可溶性α-Klotho 持续血糖监测 糖尿病 2型 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]