高龄男性2型糖尿病合并新型冠状病毒感染患者临床特点及死亡因素研究  

Clinical characteristics and death factors of elderly male patients with type 2 diabetes mellitus complicated with coronavirus infectious disease

作　　者：顾亚苹 徐茜 韩香 赵静 文婕 鞠海兵 GU Yaping;XU Qian;HAN Xiang(Department of Endocrinology,92Oth Hospital of Joint Logistics Support Force of The Chinese People's Liberation Army,Kumming 650032,China)

机构地区：[1]中国人民解放军联勤保障部队第九二〇医院内分泌科,昆明650032 [2]中国人民解放军联勤保障部队第九二〇医院干部病房,昆明650032

出　　处：《中国糖尿病杂志》2024年第5期369-372,共4页Chinese Journal of Diabetes

摘　　要：目的 探讨高龄男性T2DM合并新型冠状病毒感染(COVID-19)患者临床特点及死亡因素。方法 选取2022年12月至2023年2月于我院住院治疗的高龄男性T2DM合并COVID-19患者55例,分为生存组(n=32)和死亡组(n=23),比较两组临床及生化指标并行多因素分析,明确其临床特点及死亡的危险因素。结果 死亡组年龄、DM病程、C-RP、降钙素原(PCT)、血肌酐(Scr)、肌酸激酶、肌红蛋白、肌钙蛋白(cTn)、B型钠尿肽(BNP)、D-二聚体(D-D)、FPG及HbA_(1)c高于生存组(P<0.05或P<0.01),淋巴细胞计数(Lym)、氧分压(PaO_(2))低于生存组(P<0.05)。高龄、C-RP、PCT、Scr、cTn、BNP、D-D、FPG和HbA_(1)c升高,Lym和PaO_(2)降低是死亡的危险因素。结论 高龄男性T2DM合并COVID-19患者年龄、血糖控制、心肾肺功能以及血栓风险对评估患者预后有重要意义。Objective To explore the clinical characteristics and death factors of elderly male with type 2 diabetes mellitus(T2DM) complicated with coronavirus infectious disease 2019(COVID-19).Methods A total of 55 hospitalized elderly male T2DM patients with COVID-19 were enrolled in this study from December 2022 to February 2023.All the patients were divided into survival group(n=32) and death group(n=23).The clinical indicators were compared between the two groups and evaluated by multifactor analysis to clarify their clinical characteristics and death risk factors.Results Age,T2DM duration,C-RP,procalcitonin,serum creatinine,creatine kinase,myoglobin,BNP,troponin,D-dimer,FPG and HbA_(1c) were higher(P<0.05 or(P<0.01),while lymphocyte count and PaO_(2) were lower(P<0.05) in death group than in survival group.The advanced age,C-RP,procalcitonin,serum creatinine,troponin,BNP,D-dimer,increase of FPG and HbA_1c,and the reduction of lymphocyte count and PaO_(2) were risk factors for death(P<0.05).Conclusion Age,blood glucose control,cardiac renal and pulmonary functions,and risk of thrombosis in elderly male T2DM with COVID-19 have important significance inevaluating the prognosis.

关 键 词：高龄 男性 糖尿病 2型 新型冠状病毒感染 

分 类 号：R587.2[医药卫生—内分泌] R563.1[医药卫生—内科学]