一站式驰豫定量(MAGiC)技术预测前列腺移行带PI-RADS 3分病灶良恶性能力的临床价值  

Clinical value of MAGnetic resonance image compilation(MAGiC)for differentiating benign and malignant lesions of PI-RADS 3 in transitional zone of prostate

作　　者：徐文娟 杜芳[1] 薛松[1] 管懋彬 戚庭月[2] 朱珠 XU Wen-juan;DU Fang;XUE Song(Department of Radiology,the Affiliated Hospital of Yangzhou University,Yangzhou University,Jiangsu 225009,China)

机构地区：[1]扬州大学附属医院放射科,扬州大学,江苏225009 [2]扬州大学附属医院超声科,扬州大学,江苏225009

出　　处：《放射学实践》2024年第6期772-778,共7页Radiologic Practice

基　　金：2022年度扬州市社会发展指导性项目(YZ2022104)。

摘　　要：目的:探讨MAGiC技术鉴别前列腺移行带PI-RADS 3分病灶良恶性的临床价值。方法:回顾性分析134例患者共134个前列腺移行带PI-RADS 3分病灶的MAGiC定量图谱图像,测量并比较移行带PI-RADS 3分病灶(前列腺癌与前列腺良性增生)的MAGiC定量参数(T1、T2及PD值)差异,观察这3个定量参数在PCa诊断中的最佳诊断界值、敏感性、特异性、PPV、NPV、95%CI以及约登指数。结果:前列腺移行带PI-RADS 3分病灶中PCa的T1、T2、PD值分别为(1171.86±25.75)ms、(74.41±1.13)ms、(66.16±1.45)pu,均低于良性增生病灶。T1、T2和PD值诊断前列腺移行带PI-RADS 3分病灶中PCa的AUC值分别为0.617、0.820和0.549;三者的敏感度、特异度、PPV和NPV分别为47.06%、83.13%、63.20%、71.90%,76.47%、80.72%、70.90%、84.80%和47.06%、85.54%、66.70%、72.40%,三者的95%CI分别为0.529~0.700、0.745~0.881、0.460~0.635,约登指数分别为0.302、0.572、0.326。T2值的最佳诊断界值为77ms。结论:MAGiC定量参数的T2值具有预测列腺移行带PI-RADS 3分病灶良恶性的能力,从而减少不必要的穿刺活检。Objective:To investigate the clinical value of MAGiC technique in differentiating benign and malignant lesions of PI-RADS 3 in the transition zone of the prostate.Methods:134 patients with 134 PI-RADS 3 lesions in transitional zone of prostate were included retrospectively.We measured and compared the MAGiC quantitative parameters(T1,T2 and PD values)between different PI-RADS 3 lesions in the transition zone of the prostate(prostate cancer and prostatic benign hyperplasia),and observed the optimal diagnostic cut-off value,sensitivity,specificity,PPV,NPV,95%CI and Youden index of these three quantitative parameters in PCa diagnosis.Results:In PI-RADS 3 lesions in transition zone of prostate,the T1,T2,and PD values of PCa were(1171.86±25.75)ms,(74.41±1.13)ms,and(66.16±1.45)pu,respectively,which were lower than those of benign hyperplasia lesions.The AUC values of T1,T2,and PD values diagnosing PCa in PI-RADS 3 lesions in transition zone of prostate were 0.617,0.820,and 0.549,respectively.The sensitivity,specificity,PPV,and NPV were 47.06%,83.13%,63.20%,and 71.90% for T1 value,76.47%,80.72%,70.90%,and 84.8% for T2 value,and 47.06%,85.54%,66.70%,and 72.40% for PD value,respectively.The 95% confidence interval were 0.529~0.700,0.745~0.881 and 0.460~0.635,respectively.The Youden index were 0.302,0.572,and 0.326,respectively.The optimal diagnostic cut-off value of the T2 value was 77ms.Conclusion:The T2 value of MAGiC technique can quantitatively predict the benign and malignant lesions of PI-RADS 3 lesions in the transition zone of the prostate,which can reduce unnecessary puncture biopsy.

关 键 词：磁共振成像 前列腺 预测 

分 类 号：R445.2[医药卫生—影像医学与核医学] R322.64[医药卫生—诊断学] R-05[医药卫生—临床医学]