雾化吸入干扰素α2b注射液治疗呼吸道合胞病毒肺炎患儿的临床疗效及对免疫功能的影响  

Clinical Efficacy of Nebulized Inhaled Interferonα2b Injection in the Treatment of Children with Respiratory Syncytial Virus Pneumonia and Its Effect on Immune Function

作　　者：董静 张秀英 赵亚楠 安小康[2] DONG Jing;ZHANG Xiu-ying;ZHAO Ya-nan;AN Xiao-kang(Pediatric Department of Kaifeng Children's Hospital,Kaifeng 475000,Henan Province,China;Department of Thoracic Surgery,the First Affiliated Hospital of Henan University,Kaifeng 475000,Henan Province,China)

机构地区：[1]开封市儿童医院儿科,河南开封475000 [2]河南大学第一附属医院胸外科,河南开封475000

出　　处：《罕少疾病杂志》2024年第6期41-43,共3页Journal of Rare and Uncommon Diseases

基　　金：河南省医学科技攻关计划项目(LHGJ20210553)。

摘　　要：目的 探究雾化吸入干扰素α2b注射液治疗呼吸道合胞病毒肺炎(RSVP)患儿的临床疗效及对免疫功能的影响。方法 选取2019年11月~2023年5月本院收治的RSVP患儿68例,根据治疗方案分组,对照组(n=38)采用常规对症治疗,观察组(n=30)另外给予雾化吸入重组人干扰素α2b注射液。对比分析两组的临床疗效、肺功能、免疫功能以及炎症因子水平。结果结果 两组患儿治疗前各项指标之间的差异均不显著(P>0.05)。治疗后,与对照组相比,观察组临床总有效率、PEF、FVC、FEV1、CD3+、CD4+水平均显著升高(P<0.05);CD8+、IL-6、PCT、CRP水平均显著降低(P<0.05)。结论 对于RSVP患儿,采用雾化吸入干扰素α2b注射液治疗临床疗效较佳,能明显提高患儿的肺功能及免疫功能,有效降低患儿机体的炎症反应,值得临床采纳与推广。Objective To investigate the clinical efficacy of nebulized inhalation interferonα2b injection in the treatment of children with respiratory syncytial virus pneumonia(RSVP)and the effect on immune function.MethodsSixty-eight cases of children with RSVP admitted to our hospital from November 2019 to May 2023 were selected and grouped according to the treatment plan;the control group(n=38)was treated with conventional symptomatic therapy,and the observation group(n=30)was additionally given nebulized inhalation of recombinant human interferonα2b injection.The clinical efficacy,lung function,immune function and inflammatory factor levels of the two groups were compared and analyzed.Results The differences between the pre-treatment indicators of the children in both groups were not significant(P>0.05).After treatment,compared with the control group,the observation group's total clinical efficacy rate,PEF,FVC,FEV1,CD3+,CD4+levels were significantly higher(P<0.05);CD8+,IL-6,PCT,CRP levels were significantly lower(P<0.05).ConclusionFor children with RSVP,the use of nebulized inhalation interferonα2b injection treatment has better clinical efficacy,can significantly improve the lung function and immune function of the children,effectively reduce the inflammatory response of the children's organism,and is worthy of clinical adoption and promotion.

关 键 词：雾化吸入 干扰素α2b注射液 RSVP 临床疗效 免疫功能 

分 类 号：R725.6[医药卫生—儿科]