骨上皮样血管瘤1例并文献复习  

One Case of Epithelioid Hemangioma of Bone and Literature Review

作　　者：魏思达 龚志兵 方庆明 蒋云 饶华春 WEI Si-da;GONG Zhi-bing;FANG Qing-ming;JIANG Yun;RAO Hua-chun(Department of Pathology,Quanzhou Orthopasedic-traumatological Hospital,Quanzhou 362000,Fujian Province,China;Department of Joint,Quanzhou Orthopasedic-traumatological Hospital,Quanzhou 362000,Fujian Province,China;Department of Radiology,Quanzhou Orthopasedic-traumatological Hospital,Quanzhou 362000,Fujian Province,China)

机构地区：[1]泉州市正骨医院病理科,福建泉州362000 [2]泉州市正骨医院关节科,福建泉州362000 [3]泉州市正骨医院放射科,福建泉州362000

出　　处：《罕少疾病杂志》2024年第6期107-108,共2页Journal of Rare and Uncommon Diseases

摘　　要：目的 探讨骨上皮样血管瘤的临床特点、病理学特征、诊断与鉴别诊断。方法 研究1例原发的骨上皮样血管瘤的临床影像资料、病理形态特点、免疫组化结果,并参考相关文献进行讨论。结果 患者男性,35岁,左膝部酸痛不适1年,影像学示左股骨远端囊状低密度影,周围见硬化边缘。术后送检肿物镜下骨小梁间隙成簇的毛细血管样小血管增生,较多血管内壁衬上皮样内皮细胞,血管内皮细胞局灶呈实性的团状、片状增生,可见部分胞浆空泡状,原始血管腔形成,较多淋巴细胞与少量嗜酸性粒细胞浸润,肿物周围骨小梁增厚。免疫组化:上皮样内皮细胞CD31(+)、CD34(+)、FLI-1(+)、D2-40(-)、CK-pan(-)、Ki-67约5%阳性。结论 骨上皮样血管瘤是一种罕见血管源性肿瘤,依据影像学、形态学并结合免疫组化、基因检测可明确诊断。Objective To investigate the clinical features,pathology features,diagnosis and differential diagnosis of epithelioid hemangioma of bone.Methods The clinical data,pathological morphology characteristics and immunohistochemical results of a primary oste-oepithelioid hemangioma were discussed with relevant literature.ResultsA 35-year-old male with knee pain for 1 year showed a cystic low-density image of the distal left femur with peripheral the sclerosis.After surgery,there were clusters of small capillary-like vascular hyperplasia in the bone trabecular space.The inner wall of the blood vessels was line with more epithelioid endothelial cells,and the vascular endothelial cells were focally solid and flakelike hyperplasia.some cytoplasmic and the formation vacuolation was observed,primitive vascular lumen was fomed,more lymphocytes and a small number of eosinophils wer infiltrated,and bone trabeculae thickened around the tumor.Immunohistochemistry:vascular endothelial cells CD31(+),CD34(+),FLI-1(+),D2-40(-),CK-pan(-),about 5%postive for Ki-67.ConclusionEpithelioid hemangioma of Bone is a rare angiogenic tumor based on imaging,morphology,immunohistochemistry and combined genetic tests.

关 键 词：上皮样血管瘤 骨上皮样血管瘤 病理 

分 类 号：R322.12[医药卫生—人体解剖和组织胚胎学] R73[医药卫生—基础医学]