三项炎症因子(CRP、PCT和IL-6)联合红细胞分布宽度与血小板计数比值在早期冠心病诊断中的价值研究  

The Value of Three Inflammatory Factors(CRP,PCT and IL-6)Combined with the Ratio of Red Blood Cell Distribution Width and Platelet Count in the Diagnosis of Early Coronary Heart Disease

作　　者：石立威 赵贺红 SHI Li-wei;ZHAO He-hong(Department of Laboratory Medicine,Kaifeng People's Hospital,Kaifeng 475000,Henan Province,China)

机构地区：[1]开封市人民医院检验科,河南开封475000

出　　处：《罕少疾病杂志》2024年第6期114-116,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的 研究三项炎症因子(CRP、PCT和IL-6)联合红细胞分布宽度与血小板计数比值在早期冠心病(CHD)诊断中的价值。方法 选取2020年3月-2022年3月于我院就诊的早期CHD患者98例纳入CHD组,选取同期于我院行体检的健康志愿者98例纳入健康组作为对比,分别测定两组患者C反应蛋白(CRP)、降钙素原(PCT)、白细胞介素-6(IL-6)、红细胞分布宽度(RDW)和血小板计数(PLT),计算出RDW和PLT比值(RPR),对比三项炎症因子(CRP、PCT、IL-6)诊断与RPR进行早期CHD联合诊断与单一诊断的价值。结果 CHD组CRP、IL-6、PCT、RDW和RPR水平高于健康组,PLT水平更低(P<0.05)。三项炎症因子(CRP、IL-6、PCT)对CHD的诊断敏感度为80.61%,特异度为70.41%;RPR诊断的敏感度为81.63%,特异度为79.59%;三项炎症指标联合RPR诊断敏感度为92.86%,特异度为91.84%,高于单一诊断结果(P<0.05)。结论 采用三项炎症因子(CRP、IL-6、PCT)联合RPR对早期CHD进行诊断,具有较高的诊断价值,对于早期疾病筛查有一定意义,值得临床广泛应用。Objective to study the diagnostic value of three inflammatory factors(CRP,PCT and IL-6)combined with the ratio of red blood cell(RBC)distribution width and platelet count in early coronary heart disease(CHD).Methods98 patients with early CHD from March 2020 to March 2022 were selected as CHD Group,and 98 healthy volunteers were selected as control group,c-reactive protein(CRP),Procalcitonin(PCT),IL6(IL-6),red blood cell distribution width(RDW)and platelet count(PLT)were measured and the ratio of RDW to PLT(RPR)was calculated,to compare the diagnostic value of three inflammatory factors(CRP,PCT,IL-6)and RPR in early CHD.ResultsThe levels of CRP,IL-6,PCT,RDW and RPR in CHD group were higher than those in healthy group,and the levels of PLT were lower(P<0.05)The sensitivity and specificity of CRP,IL-6 and PCT were 80.61%and 70.41%for CHD,81.63%and 79.59%for RPR,92.86%and 79.59%for RPR,respectively,the specificity was 91.84%,which was higher than that of single diagnosis(P<0.05).ConclusionThe three inflammatory factors(CRP,IL-6,PCT)combined with RPR have high diagnostic value in early CHD,and it has certain significance for screening of early CHD and is worthy of wide clinical application.

关 键 词：早期冠心病 三项炎症因子 红细胞分布宽度 血小板计数 诊断价值 

分 类 号：R541.4[医药卫生—心血管疾病]