高胆红素血症新生儿血清CKMB NPY及β_(2)-MG的水平变化及临床意义  

Changes and Clinical Significance of Serum Creatine Kinase MB Neuropeptide Y and β_(2)-Microglobulin Levels in Hyperbilirubinemic Neonates

作　　者：李佳强 袁迅玲[2] 张冉 沈书[1] 田玲玲 LI Jiaqiang(The First Affiliated Hospital of Harbin Medical University,Heilongjiang Harbin 150010,China)

机构地区：[1]哈尔滨医科大学附属第一医院新生儿重症监护病房,黑龙江哈尔滨150010 [2]黑龙江省医院儿科,黑龙江哈尔滨150036

出　　处：《河北医学》2024年第6期923-927,共5页Hebei Medicine

基　　金：黑龙江省卫生计生委科研课题,(编号:2018220)。

摘　　要：目的:探讨高胆红素血症新生儿血清肌酸激酶同工酶(CreatineKinase-MB,CKMB)、神经肽Y(Neuropeptide Y,NPY)及β_(2)-微球蛋白(β_(2)-microglobulin,β_(2)-MG)的水平变化及临床意义。方法:选取本院2019年1月至2022年1月收治的高胆红素血症新生儿118例为观察组,根据总胆红素(total bilirubin,STB)分度分为:轻度组58例(220.6μmoL/L<STB≤256.5μmoL/L),中度组42例(256.5μmoL/L<STB≤342μmoL/L),重度组18例(STB>342μmoL/L);另选取同期于本院经皮胆红素测定无黄疸的健康新生儿112例为对照组。比较对照组、观察组CKMB、NPY及β_(2)-MG水平;比较观察组不同STB程度患者CKMB、NPY及β_(2)-MG水平;根据经皮胆红素测定的STB水平分为急性期组及恢复期组,比较急性期及恢复期两组患者CKMB、NPY及β_(2)-MG水平。结果:观察组CKMB、NPY及β_(2)-MG水平均比对照组高(P<0.05)。不同STB程度患者CKMB、NPY、β_(2)-MG水平比较:轻度组<中度组<重度组(P<0.05)。118例高胆红素血症新生儿中,急性期组67例和恢复期组51例,急性期组CKMB、NPY、β_(2)-MG水平均高于恢复期组(P<0.05)。结论:血清CKMB、NPY及β_(2)-MG与高胆红素血症新生儿病情严重程度及预后关系密切,可通过检测上述指标评估患儿病情进展及预后,具有重要临床意义。Objective:To investigate the changes and clinical significance of serum creatine kinase isoenzyme(CreatineKinase-MB,CKMB),neuropeptide Y(Neuropeptide Y,NPY),andβ_(2)-microglobulin(β_(2)-microglobulin,β_(2)-MG)levels in hyperbilirubinemic neonates.Methods:A total of 118 hyperbilirubinemic neonates admitted to our hospital from January 2019 to January 2022 were selected as the observation group.According to the total bilirubin(STB)level,they were divided into three groups:mild group(n=58,220.6μmol/L≤STB≤256.5μmol/L),moderate group(n=42,256.5μmol/L≤STB≤342μmol/L),and severe group(n=18,STB>342μmol/L).Another 112 healthy neonates without jaundice who underwent percutaneous bilirubin measurement in our hospital during the same period were selected as the control group.The levels of CKMB,NPY,andβ_(2)-MG in the control group and observation group were compared.The levels of CKMB,NPY,andβ_(2)-MG in patients with different STB levels in the observation group were compared.According to the percutaneous bilirubin-measured STB level,the patients were divided into the acute phase group and the recovery phase group,and the levels of CKMB,NPY,andβ_(2)-MG in the two groups were compared.Results:The levels of CKMB,NPY,andβ_(2)-MG in the observation group were all higher than those in the control group(P<0.05).Comparison of CKMB,NPY,andβ_(2)-MG levels in patients with different STB levels:mild group<moderate group<severe group(P<0.05).Among the 118 hyperbilirubinemic neonates,there were 67 cases in the acute phase group and 51 cases in the recovery phase group.The levels of CKMB,NPY,andβ_(2)-MG in the acute phase group were all higher than those in the recovery phase group(P<0.05).Conclusion:Serum CKMB,NPY,andβ_(2)-MG levels are closely related to the severity and prognosis of hyperbilirubinemia in neonates.Monitoring these indicators can help assess the progression and prognosis of the condition,providing significant clinical value.

关 键 词：肌酸激酶同工酶 神经肽Y β_(2)-微球蛋白 高胆红素血症 新生儿 

分 类 号：R722.1[医药卫生—儿科]