槲皮素对肝细胞性肝癌的增效减毒效应研究进展  

Research Progress of Quercetin's Effects on Hepatocellular Carcinoma by Improving Treatments and Reducting Toxicity

作　　者：李兴强 晁旭[1,2] 冯雪松 LI Xingqiang;CHAO Xu;FENG Xuesong(Basic Medical Academy,Shaanxi University of Chinese Medicine,Xianyang 712046,China;The Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712046,China)

机构地区：[1]陕西中医药大学基础医学院,咸阳712046 [2]陕西中医药大学第二附属医院,咸阳712046

出　　处：《世界科学技术-中医药现代化》2024年第2期287-293,共7页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：陕西省中医体质与疾病防治重点实验室开放课题(KF202311):痰瘀体质大鼠对肝癌的易感性及土贝母对痰瘀体质大鼠肝癌的抑制作用与分子机制研究,负责人:冯雪松;陕西中医药大学国家基金培育项目(2023GP16):土贝母联合索拉菲尼抑制肝癌细胞增殖及改善肝癌细胞对其耐药性的机制研究,负责人:冯雪松;陕西中医药大学2023年度研究生质量提升工程专项项目(CXSJ202302):“Skin Heal”三维治疗烧伤新方案,负责人:李兴强。

摘　　要：阿霉素、5-氟尿嘧啶和顺铂为临床上常用于治疗肝细胞性肝癌(Hepatocellular carcinoma,HCC)的化疗药物,化疗的同时易产生明显的毒副反应和多药耐药,影响治疗效果。因此,开发新型有效药物降低化疗引起的副作用势在必行。槲皮素是一种在安全剂量范围内天然无毒的黄酮醇类化合物,在过去的几十年里,槲皮素的多种抗肿瘤作用及其机制已被逐步挖掘,如促凋亡、抗增殖、抗炎和抗氧化作用等;槲皮素不仅能够增强化疗效果,还能够降低化疗中的不良反应。本文总结了槲皮素对HCC化疗药物增效减毒效应的研究概况,并展望了槲皮素作为治疗HCC的辅助药物应用于临床的发展前景。Doxorubicin,5-fluorouracil and cisplatin are commonly used in the treatment of hepatocellular carcinoma.These drugs shows obvious toxic side effects and patients always get multidrug resistance while using these drugs during chemotherapy.These effects hinder the progress and treatments of chemotherapy.Therefore,it has become imperative to develop new and effective drugs to prevent the side effects caused by chemotherapy.Quercetin is a naturally non-toxic flavonol within a safe dose range.In the past few decades,anti-tumor mechanisms of quercetin have been studied,such as pro-apoptotic,antiproliferative,anti-inflammatory and antioxidant effects.Several reports in recent years have found that quercetin plays an important role in adverse effects of anti-chemotherapy drugs and enhancing the efficacy of drugs.This article summarizes the research overview of the synergistic and antitoxicity effect of quercetin on the abovementioned chemotherapy drugs for hepatocellular carcinoma.This review indicates the clinical potential of quercetin as an adjuvant drug for the treatment of hepatocellular carcinoma.

关 键 词：槲皮素 肝细胞性肝癌 化疗药物 增效减毒 

分 类 号：R285[医药卫生—中药学]