免疫炎症在冠心病中的作用及中医药研究进展  

Advances in Immune-inflammatory Mechanisms of Coronary Heart Disease and Traditional Chinese Medicine Research

作　　者：何浩强[1] 戴泽琦 高嘉良[1] 崔景润 曹琳琳 张振鹏[1] 李军[1] 王阶[1] HE Haoqiang;DAI Zeqi;GAO Jialiang;CUI Jingrun;CAO Linlin;ZHANG Zhenpeng;LI Jun;WANG Jie(Guang'anmen Hospital,China Academy of Chinese Medical Sciences;Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences)

机构地区：[1]中国中医科学院广安门医院,北京100053 [2]中国中医科学院中医临床基础医学研究所,北京100700

出　　处：《世界科学技术-中医药现代化》2024年第2期523-529,共7页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委员会面上项目(81974556):冠心病稳定型心绞痛痰瘀互结证多组学网络模块整合研究,负责人:王阶。

摘　　要：免疫炎症是贯穿冠心病发生发展的关键病理环节之一,其中固有免疫相关细胞(单核细胞等)和适应性免疫相关细胞(T细胞等)在冠状动脉粥样硬化的发生过程中扮演重要角色。研究发现,通过调节免疫炎症可以发挥抗动脉粥样硬化的作用,免疫炎症成为临床治疗的新靶点,部分疫苗与抗体已陆续开展临床试验,并显示出一定的临床疗效。探索中医药在冠心病免疫炎症的作用机制,或能为中药新药研发提供新的思路。Immune inflammation is one of the critical pathological processes linking to the development of coronary heart disease,in which innate immune-related cells(monocytes,etc.)and adaptive immune-related cells(T cells,etc.)play an important role in this process.Numerous studies have found that regulating immune inflammation can inhibit atherosclerosis.Immune inflammation has become a new therapeutic target,while some vaccines and antibodies have been carried out clinical trials,and show certain clinical efficacy.Exploring the mechanism of traditional Chinese medicine on immune inflammation of coronary heart disease may provide new ideas for the research and development of new traditional Chinese medicine.

关 键 词：冠心病 动脉粥样硬化 免疫 炎症 中医药 

分 类 号：R541.4[医药卫生—心血管疾病]