基于“肺毛细血管通透性”异常试论IPF中医络瘀病机之生物学基础  

On the Biological Basis of the Pathogenesis of Collaterals and Blood Stasis in IPF Based on the Abnormality of Pulmonary Capillary Permeability

作　　者：崔钰伟 臧凝子[2,3] 王佳然 邹吉宇 庞立健[2] 吕晓东[5] CUI Yuwei;ZANG Ningzi;WANG Jiaran;ZOU Jiyu;PANG Lijian;LYU Xiaodong(First Clinical College of Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China;The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China;School of Chinese Medicine of Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China;Graduate School of Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China;Office of Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China)

机构地区：[1]辽宁中医药大学第一临床学院,沈阳110847 [2]辽宁中医药大学附属医院,沈阳110032 [3]辽宁中医药大学中医学院,沈阳110847 [4]辽宁中医药大学研究生学院,沈阳110847 [5]辽宁中医药大学机关,沈阳110847

出　　处：《世界科学技术-中医药现代化》2024年第2期530-536,共7页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金青年基金项目(82004294):清络饮调控IL-6/STAT3/Lin28B/let-7d环路平衡干预炎症刺激上皮间充质转化治疗特发性肺纤维化急性加重机制研究,负责人:臧凝子;国家自然科学基金面上项目(82274440):益气养阴活血通络法调控周细胞-内皮细胞Ang/Tie2信号恢复内皮生态位改善血管通透性治疗IPF机制研究,负责人:吕晓东;辽宁中医药大学“中医藏象理论及应用教育部重点实验室”开放基金(zyzx2210):参苓补肺通络汤下调HIF-1α信号抑制线粒体自噬改善COPD合并骨骼肌功能障碍机制研究,负责人:臧凝子。

摘　　要：特发性肺纤维化近年来因其治疗成本、发病率、死亡率高而备受重视,因此寻找有效且价格低廉的治疗方法和药物已经成为有待解决的难题。络病理论治疗IPF具有独特优势,基于络病理论的指导下IPF病机认识提出“络瘀”病机贯穿IPF整个病理阶段,然其物质基础尚不清楚。本文通过对特发性肺纤维化发病机制的深入研究,梳理肺毛细血管通透性增强、肺血管渗漏在IPF病理进程中的作用,并从络病理论出发,进一步揭示IPF中医“络瘀”病机的生物学基础,为络病理论指导下“通络”治法的应用奠定基础,为以络论治IPF的中医思路提供有力科学依据,为中医药治疗IPF提供新思路。In recent years,idiopathic pulmonary fibrosis has attracted much attention because of its high treatment cost,morbidity and mortality.Therefore,finding effective and low-cost treatment methods and drugs has become a difficult problem to be solved.The theory of collaterals disease has unique advantages in treating IPF.Based on the guidance of the theory of collateral disease,it is proposed that the pathogenesis of"collateral stasis"runs through the whole pathological stage of IPF,but its material basis is still unclear.In this article,through the in-depth study of the pathogenesis of idiopathic pulmonary fibrosis,the role of enhanced pulmonary capillary permeability and pulmonary vascular leakage in the pathological process of IPF was sorted out.Based on the theory of collateral disease,the biological basis of the pathogenesis of"collateral stasis"in IPF was further revealed,lays a foundation for the application of"gredging collaterals"therapy under the guidance of collateral disease theory,provides scientific basis for TCM treatment of IPF by collateral theory,and provides new ideas for TCM treatment of IPF.

关 键 词：络瘀 IPF 病机 血管通透性 通络 

分 类 号：R563.1*9[医药卫生—呼吸系统]