新型冠状病毒感染合并李斯特菌脑膜炎1例并文献复习  

SARS-CoV-2 infection combined with Listeria meningitis:A case report and literature review

作　　者：只丙娣 刘英[1] 刘莹[1] 张复波[1] 李俊峰[1] Zhi Bingdi;Liu Ying;Liu Ying;Zhang Fubo;Li Junfeng(Department of General Medical,Tianjin First Central Hospital,Xiqing 300380,China)

机构地区：[1]天津市第一中心医院全科医学科,天津西青300380

出　　处：《临床荟萃》2024年第4期347-351,共5页Clinical Focus

摘　　要：目的提高对新型冠状病毒及单核细胞增多性李斯特菌(Listeria monocytogenes,LM)脑膜炎的认识,增强临床医生对李斯特菌病的诊治水平。方法回顾性分析新型冠状病毒感染合并LM脑膜炎患者1例,并进行文献学习。结果患者女性,77岁,以发热、头痛起病,合并新型冠状病毒感染,通过脑脊液培养及血培养检查,确诊为LM脑膜炎,经过足量青霉素联合庆大霉素、后改为美罗培南抗感染治疗,临床症状缓解,病情得到有效控制。结论针对新型冠状病毒感染和免疫功能紊乱的患者,积极治疗基础病,改善机体免疫状态是关键,一旦确诊李斯特菌病,足量、足疗程应用敏感抗生素对改善预后至关重要。Objective To improve the understanding of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection and Listeria monocytogenes(LM)meningitis,thus strengthening the level of diagnosis and treatment of Listeria infections in clinicians.Methods A case of SARS-CoV-2 infection combined with LM meningitis was retrospectively analyzed,and the literatures were reviewed.Results A 77-year-old femal patient started with fever and headache,combined with SARS-CoV-2 infection,was diagnosed as LM meningitis through cerebrospinal fluid culture and blood culture.After sufficient penicillin combined with gentamicin,and meropenem subsequent for anti-infection treatment,the patient's clinical symptoms were significantly relieved,and the disease was effectively controlled.Conclusion For patients with infection of SARS-CoV-2 and immune disorders,curative care of basic diseases and improvement of immune status are the key.Once listeriosis is diagnosed,the application of sufficient and adequate treatment period of sensitive antibiotics is crucial to improve the prognosis.

关 键 词：脑膜炎 利斯特菌性 单核细胞增多性李斯特菌 新型冠状病毒感染 抗菌药 

分 类 号：R515.2[医药卫生—内科学] R563.12[医药卫生—临床医学]