多模态磁共振功能成像中MAGIC对比DTI在帕金森病的应用价值  

Application of DTI Combined with MAGiC for Parkinson's Disease in Multimodal Magnetic Resonance Functional Imaging

作　　者：祁金鹏 张岗 张锐 陈苗 梁智博 王文佳 QI Jin-peng;ZHANG Gang;ZHANG Rui;CHEN Miao;LIANG Zhi-bo;WANG Wen-jia(Imaging Department,Hulunbuir People's Hospita,Hulunbuir 021008,Inner Mongolia,China;Nuclear Magnetic Resonance Production Department,General Electric Medical System Trade Development(Shanghai)Co.,Ltd.,Beijing 100176,China)

机构地区：[1]呼伦贝尔市人民医院影像科,内蒙古呼伦贝尔021008 [2]通用电气医疗系统贸易发展(上海)有限公司核磁共振产品部,北京100176

出　　处：《中国CT和MRI杂志》2024年第6期24-26,共3页Chinese Journal of CT and MRI

基　　金：内蒙古自治区应用技术研究与开发资金(2020GG0179)。

摘　　要：目的 探讨多模态MRI技术中弥散张量成像(diffusion tensor imaging,DTI)序列与定量图谱磁共振成像技术(magnetic resonance image complication,MAGIC)序列在帕金森病(PD)中的诊断价值。方法 在我院使用3.0T美国通用公司(GE)pioneer机型对PD患者及健康对照组(NC组)进行扫描,记录感兴趣区的壳核、尾状核头、黑质、海马旁回、颞叶的T1MAP、T2MAP、PDMAP及各向异性分数(fractional anisotropy,FA)值变化,纳入2019年6月至2021年6月PD患者31例及NC组25例,采集所研究对象的MAGiC、DTI序列并进行ROI选取、勾画、数据统计与分析。结果 MAGIC中T1MAP在壳核、海马旁回(左)、颞叶,T2MAP在壳核(左)、尾状核(右)、海马旁回(左)、颞叶,PDMAP在海马旁回(左)、颞叶的MAP值均低于NC组,差异具有统计学意义(P<0.05),其他各部位均无显著差异(P>0.05)。同时ROC显示海马旁回、颞叶的T1MAP的诊断AUC分别为0.812与0.821,在T2MAP的诊断AUC为0.73与0.786,在FA的诊断AU C仅为0.338与0.332,颞叶的诊断价值高于海马旁回;T1MAP诊断价值高于T2MAP、FA。结论 多模态MRI技术中MAGIC与DTI比较显示,MAGIC序列对PD的诊断效能高于DTI序列,T1MAP显著优于T2MAP及FA值。颞叶、海马旁回T1MAP值减低对PD的诊断具有一定价值,且有望在临床应用中推广。Objective To evaluate the diagnostic value of the diffusion tensor imaging(DTI) sequence and magnetic resonance image complication(MAGIC) sequence in multimodal magnetic resonance imaging(MRI)for Parkinson's disease(PD).Methods A total of 31 PD patients and 25 healthy control patients were included in the study from June 2019 to June 2021,and were scanned using the 3.0T GE Pioneer model at our hospital.T1MAP,T2MAP,PDMAP,and fractional anisotropy(FA) values were recorded in the putamen,caudate head,substantia nigra,parahippocampal gyrus,and temporal lobe.ROI selection,mapping,data statistics,and analysis were conducted on the MAGiC and DTI sequences of the su bjects.The MAP values of T1MAP in the putamen,pa rahippocampal gyrus(left),and temporal lobe,T2MAP in the putamen(left),caudate nucleus(right),parahippocampal gyrus(left),and PDMAP in the parahippocampal gyrus(left),were lower in PD patients than in the healthy control group,with statistical significance(P<0.05).The ROC analysis showed that the diagnostic AUCs of T1MAP in the parahippocampal gyrus and temporal lobe were 0.812 and 0.821,respectively,that of T2MAP was 0.73 and 0.786,and that of FA was 0.338 and 0.332.Therefore,the diagnostic value of the temporal lobe was higher than that of the parahippocampal gyrus,and the diagnostic value of T1MAP was higher than that of T2MAP and FA.Conclusion The combination of MAGIC and DTI sequences in multimodal MRI showed higher diagnostic efficacy for PD in the temporal lobe than in the parahippocampal gyrus,and T1MAP was found to be more effective than T2MAP and FA.

关 键 词：帕金森病 多模态 定量图谱磁共振成像技术 弥散张量成像 各向异性分数 

分 类 号：R445.2[医药卫生—影像医学与核医学]