支气管扩张合并感染患者血清PCT、CRP、IL-33水平变化及临床意义  

Changes and clinical significance of serum PCT,CRP and IL-33 levels in patients with bronchiectasis and infection

作　　者：陈晓凤 田海霞 Chen Xiaofeng;Tian Haixia(Department of Clinical Laboratory,Taiyuan Hospital of Traditional Chinese Medicine,Taiyuan 030000,China)

机构地区：[1]太原市中医医院检验科,山西太原030000

出　　处：《现代科学仪器》2024年第3期146-150,共5页Modern Scientific Instruments

摘　　要：目的:分析支气管扩张合并感染患者血清降钙素原(PCT)、C-反应蛋白(CRP)、白细胞介素33(IL-33)水平变化及临床意义。方法:选择2021年9月~2023年9月期间收治的60例支气管扩张合并感染患者为研究组,以30例同期同一医院的健康体检者和支气管扩张未合并感染患者为对照1组、对照2组,比较三组血清PCT、CRP、IL-33水平。根据患者支气管扩张程度和感染程度对研究组进行分组,比较研究组亚组间的血清PCT、CRP、IL-33水平变化。采用logistic回归分析支气管扩张合并感染和血清PCT、CRP、IL-33之间的关系,以曲线下面积(AUC)表示诊断价值。结果:研究组血清PCT、CRP、IL-33水平均高于对照1组、对照2组,且对照2组血清PCT、CRP、IL-33水平高于对照1组,差异有统计学意义(P<0.05)。随着支气管扩张程度加重,血清PCT、CRP、IL-33水平显著增加,重度扩张组血清PCT、IL-33水平高于轻度扩张组、中度扩张组,中度扩张组血清CRP水平高于轻度扩张组,差异有统计学意义(P<0.05)。随着感染程度加重,血清PCT、CRP、IL-33水平显著增加,重度感染组血清PCT、CRP、IL-33水平高于轻度感染组、中度感染组,中度感染组血清PCT、CRP、IL-33水平高于轻度感染组,差异有统计学意义(P<0.05)。logistic回归分析结果显示,PCT、IL-33是支气管扩张合并感染的独立危险因素(P<0.05)。血清PCT AUC为0.897,敏感度、特异度为75.33%、97.64%;血清IL-33 AUC为0.0.787,敏感度、特异度为55.00%、93.33%。结论:支气管扩张合并感染患者血清PCT、CRP、IL-33水平会显著升高,PCT和IL-33对支气管扩张合并感染有较高诊断价值。Objective:To analyze the changes and clinical significance of serum procalcitonin(PCT),C-reactive protein(CRP)and interleukin-33(IL-33)levels in patients with bronchiectasis and infection.Methods:Sixty patients with bronchiectasis and infection who were admitted to the hospital from September 2021 to September 2023 were selected as the study group.At the same time,30 healthy individuals and patients with bronchiectasis but without infection were selected as the control group 1 and the control group 2,respectively.Serum PCT,CRP and IL-33 levels were compared among the three groups.Patients in the study group were grouped according to the severity of bronchiectasis and infection.Serum PCT,CRP and IL-33 levels in subgroups of the study group were compared.Logistic regression analysis was conducted to discuss the relationship between bronchiectasis complicated with infection and serum PCT,CRP and IL-33.The area under curve(AUC)was used to represent the diagnostic value.Results:Serum PCT,CRP and IL-33 levels decreased in sequence from the study group,the control group 2 to the control group 1,with statistically significant differences between groups(P<0.05).With the aggravation of bronchiectasis,serumPCT,CRP,and IL-33 levels increased.SerumPCT and IL-33 levels in the severe bronchiectasis group were higher than those in the mild bronchiectasis group and the moderate bronchiectasis group.Serum CRP level in the moderate bronchiectasis group was higher than that in the mild bronchiectasis group(P<0.05).With the aggravation of infection,serumPCT,CRP,and IL-33 levels increased.SerumPCT,CRP,and IL-33 levels in the severe infection group were higher than those in the mild infection group and the moderate infection groups.SerumPCT,CRP,and IL-33 levels in the moderate infection group were higher than those in the mild infection group(P<0.05).Logistic regression analysis found that PCT and IL-33 were independent risk factors for bronchiectasis complicated with infection(P<0.05).The AUC,sensitivity and specificity of serum PCT w

关 键 词：支气管扩张 感染 血清 降钙素原、C-反应蛋白、白细胞介素33 诊断价值 

分 类 号：R562.22[医药卫生—呼吸系统]