基于动态硼酸酯键构建双重刺激响应型介孔氧化硅  

Construction of dual stimulus-responsive mesoporous silica based on dynamic borate ester bonds

作　　者：许凡 赵文丽 吉庆敏 Xu Fan;Zhao Wenli;Ji Qingmin(School of Materials Science and Engineering/Herbert Gleiter Institute,Nanjing University of Science and Technology,Nanjing 210094,China)

机构地区：[1]南京理工大学材料科学与工程学院/格莱特研究院,江苏南京210094

出　　处：《南京理工大学学报》2024年第3期397-404,共8页Journal of Nanjing University of Science and Technology

基　　金：国家自然科学基金(21875108);南京理工大学校自主科研专项计划(30921013106)。

摘　　要：该文通过化学修饰介孔氧化硅,利用动态硼酸酯键构建了新型可控释放体系。采用阴离子辅助法合成了具有独特中心径向孔结构和孔径大于4 nm的介孔氧化硅纳米颗粒,并在其孔内外表面接枝苯硼酸。当体系中添加含顺式二醇键的聚合物时,可以与孔表面的苯硼酸形成硼酸酯键,产生对孔道空间的调节效应,从而实现介孔氧化硅纳米颗粒内不同程度的分子负载。利用硼酸酯键的动态反应性(pH值为酸性时水解断键;与过氧化氢发生氧化断键),成功调控了孔道内负载染料分子的响应释放行为。该文研究结果对于开拓构建基于氧化硅结构的可控释放结构、发展高效药物传输体系具有奠定理论和试验基础的意义。In this work,a new controlled release system based on mesoporous silica nanoparticles was constructed by regulating the formation of borate ester bonds on the pore surfaces.Mesoporous silica nanoparticles with unique central radial pore structure and pore size greater than 4 nm were synthesized by an anion-assisted method.The inner and outer surfaces of the pores were grafted with phenylboronic acid groups through chemical modification.In adding the polymers containing the cis-diol bonds,the borate ester can form with phenylboronic acid,which may regulate the pore space and lead to different loading levels of molecules in the nanoparticles.Relying on the dynamic reactivity of borate ester bonds in the pores(hydrolysis and bond breaking when the pH value is acidic;oxidation and bond breaking with hydrogen peroxide),the release behavior of the encapsulated dyes in the pore can be successfully regulated according to the stimulus-responsive reactions.The results of this study may expand the fabrication strategies of silica structures for controlled release structures and promote the development of efficient drug delivery systems.

关 键 词：介孔氧化硅 硼酸酯键 双重刺激响应 分子载体 可控释放 

分 类 号：TH145.1[一般工业技术—材料科学与工程]