三维能量多普勒超声预测宫颈癌化疗效果的临床价值  

Clinical value of three-dimensional power Doppler ultrasound in predicting the chemotherapy effect for cervical cancer

作　　者：陈高进[1] 李瑞霞 冯菲[1] CHEN Gaojin;LI Ruixia;FENG Fei(Department of Ultrasound Medicine,the First Hospital of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学第一医院超声医学科,兰州市730000

出　　处：《临床超声医学杂志》2024年第6期471-474,共4页Journal of Clinical Ultrasound in Medicine

摘　　要：目的探讨三维能量多普勒超声(3D-PDU)预测宫颈癌化疗效果的临床应用价值。方法选取在我院接受新辅助化疗治疗的宫颈癌患者160例,根据化疗效果分为有效组103例和无效组57例,比较两组3D-PDU血流参数[血管形成-血流指数(VFI)、血流指数(FI)及血管形成指数(VI)]的差异。采用多因素Logistic回归分析筛选预测宫颈癌患者化疗效果的独立危险因素,并建立宫颈癌患者化疗效果风险预测模型;采用Hosmer-Lemeshow检验评估模型的拟合度;绘制受试者工作特征(ROC)曲线分析模型的预测效能。结果化疗后,两组VFI、FI及VI均较化疗前下降,且有效组上述参数均低于无效组,差异均有统计学意义(均P<0.05)。多因素Logistic回归分析显示,化疗后VFI、FI及VI均为预测宫颈癌患者化疗效果的独立危险因素(OR=2.826、4.637、3.216,均P<0.05),建立宫颈癌患者化疗效果风险预测模型为:Logit(P)=1/[1+e^((-4.609+1.039×化疗后VFI+1.534×化疗后FI+1.168×化疗后VI))]。Hosmer-Lemeshow检验显示模型的拟合度较好(χ^(2)=4.635,P=0.781);ROC曲线分析显示模型预测宫颈癌患者化疗效果的曲线下面积为0.882(P<0.05)。结论应用3D-PDU可以较好地预测宫颈癌化疗效果,具有一定的临床应用价值。Objective To explore the clinical application value of three-dimensional power Doppler ultrasound(3D-PDU)in predicting the chemotherapy effect for cervical cancer.Methods A total of 160 patients with cervical cancer in our hospital were selected and treated with neoadjuvant chemotherapy.According to the chemotherapy effect,they were divided into the effective group(103 cases)and the ineffective group(57 cases).The 3D-PDU blood flow parameters[vascularization-flow index(VFI),flow index(FI)and vascularization index(VI)]between the two groups were compared.Multivariate Logistic regression analysis was used to screen the independent risk factors for predcting the chemotherapy effect in patients with cervical cancer,and the risk prediction model was established.Hosmer-Lemeshow test was used to evaluate the fitting degree of the model,and the receiver operating characteristic(ROC)curve was drawn to analyze the predictive efficacy.Results After chemotherapy,the VFI,FI and VI of the two groups were significantly lower than those before chemotherapy(all P<0.05),and the above parameters in the effective group were lower than those in the ineffective group(all P<0.05).Multivariate Logistic regression analysis showed that VFI,FI and VI after chemotherapy were independent risk factors for predicting chemotherapy effect in patients with cervical cancer(OR=2.826,4.637,3.216,all P<0.05).The risk prediction model for the chemotherapy effect in patients with cervical cancer was established as follows:Logit(P)=1/[1+e^((-4.609+1.039×VFIafterchemotherapy+1.534×FIafterchemotherapy+1.168×VIafterchemotherapy))].Hosmer-Lemeshow test showed that the fitting degree of the model was good(χ^(2)=4.635,P=0.781).ROC curve analysis showed that the area under the curve of the model for predicting the chemotherapy effect in patients with cervical cancer was 0.882(P<0.05).Conclusion 3D-PDU could better predict the chemotherapy effect for cervical cancer,and has a certain aclinical application value.

关 键 词：超声检查 能量多普勒 三维 宫颈癌 化疗效果 预测模型 

分 类 号：R445.1[医药卫生—影像医学与核医学] R737.33[医药卫生—诊断学]