海藻酸钠复合水凝胶的制备及在中药挥发油缓释领域的应用进展  

Progress of Preparation of Sodium Alginate Composite Hydrogel and Its Application in the Field of Slow Release of Essential Oil in Traditional Chinese Medicine

作　　者：俞树琴 王芸 周强 陈晖 刘雪枫 刘雄 施小宁 高建德 Shuqin Yu;Yun Wang;Qiang Zhou;Hui Chen;Xuefeng Liu;Xiong Liu;Xiaoning Shi;Jiande Gao(College of Pharmacy,Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China;Northwest Chinese-Tibetan Medicine Collaborative Innovation Center of Ministry of Education,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学药学院,甘肃兰州730000 [2]省部共建教育部西北中藏药协同创新中心,甘肃兰州730000

出　　处：《高分子材料科学与工程》2024年第4期175-181,共7页Polymer Materials Science & Engineering

基　　金：国家自然科学基金资助项目(82060821);甘肃省科技计划项目(22YF7FA125);兰州市人才创新创业项目(2020-RC-65);甘肃省中医药管理局科研课题项目(GZK-2019-22);甘肃省“双一流”科研重点项目(GSSYLXM-05)。

摘　　要：海藻酸钠由于来源广泛、价格低廉,分子中含有大量的羧基、羟基,在较为温和的环境中,能够迅速地构成三维网状结构的水凝胶而受到了人们的广泛关注,但单一的海藻酸钠水凝胶力学性能和力学强度较差。当与其他物质形成复合水凝胶后则因其优异的生物相容性、生物降解性和pH敏感性被广泛应用于敏感药物的缓控释领域。文中主要介绍了海藻酸钠复合水凝胶的相应制备方法和性能,以及在中药挥发油缓释领域的应用进展,同时指出了海藻酸钠复合水凝胶在中药挥发油缓释领域存在的问题及未来主要的研究方向。Sodium alginate has attracted wide attentions due to its wide source,low price,large amount of carboxyl group and hydroxyl group in molecule.In relatively mild environment,sodium alginate can quickly form a three-dimensional network structure of hydrogels.However,the single sodium alginate hydrogel has poor mechanical properties and mechanical strength,and sodium alginate composite hydrogels formed with other substances have been widely used in the field of slow and controlled release of sensitive drugs due to its excellent biocompatibility,biodegradability and pH sensitivity.This paper mainly introduced the preparation methods and properties of sodium alginate composite hydrogels,as well as the application progress in the field of slow release of essential oil in traditional Chinese medicine,and pointed out the existing problems and future research directions of sodium alginate composite hydrogels in the field of slow release of essential oil in traditional Chinese medicine.

关 键 词：海藻酸钠复合水凝胶 中药挥发油 缓释 

分 类 号：TQ427.26[化学工程]