双歧杆菌联合维生素K1治疗黄疸患儿的疗效及其对炎症指标的影响  

Curative effect of bifidobacterium combined with vitamin k1 in the therapy of children with jaundice and its influence on inflammation indexes

作　　者：王静[1] 吴项英 强中洋 WANG Jing;WU Xiang-ying;QIANG Zhong-yang(Department of Pediatric Internal Medicine,the Affiliated Chuzhou Hospital of Anhui Medical University,Chuzhou 239000,Anhui,China;Department of Pediatric Ward II,the Affiliated Chuzhou Hospital of Anhui Medical University,Chuzhou 239000,Anhui,China)

机构地区：[1]安徽医科大学附属滁州医院儿内科,安徽滁州239000 [2]安徽医科大学附属滁州医院儿科二病区,安徽滁州239000

出　　处：《川北医学院学报》2024年第6期754-757,共4页Journal of North Sichuan Medical College

基　　金：安徽省自然科学基金(2008085QG345)。

摘　　要：目的:探讨双歧杆菌联合维生素K1治疗黄疸患儿的疗效及对其炎症指标的影响。方法:将102例黄疸患儿按照治疗方式不同分为对照组和试验组,每组各51例。对照组患儿给予常规治疗和维生素K1治疗;试验组患儿在对照组的基础上给予双歧杆菌治疗。比较两组患儿的临床指标、疗效、黄疸指数、炎症指标及不良反应发生情况。结果:试验组患儿胎便排空、黄疸消退及住院时间均短于对照组(P<0.05),排便次数高于对照组(P<0.05)。试验组治疗总有效率高于对照组(P<0.05)。治疗后,两组患儿黄疸指数、白细胞介素6(IL-6)、C反应蛋白(CRP)及降钙素原(PCT)水平均降低(P<0.05),且试验组低于对照组(P<0.05)。两组患儿不良反应发生率无统计学差异(P>0.05)。结论:双歧杆菌联合维生素K1治疗黄疸的疗效较显著,且在改善患儿临床症状及炎症反应方面效果较好,治疗安全性高,可为临床治疗黄疸患儿提供借鉴。Objective:To explore the curative effect of bifidobacterium combined with vitamin K1 in the therapy of children with jaundice and its influence on inflammation indexes.Methods:A total of 102 children with jaundice were included and divided into control group and experimental group according to different treatment methods,with 51 cases in each group.The control group received conventional therapy and vitamin K1,and the experimental group received bifidobacterium based on the control group.The clinical indexes,therapeutic curative effect,jaundice index,inflammation indexes and the occurrence of untoward effects were compared between the two groups.Results:The time of fetal defecation,jaundice resolution and hospital stay in the experimental group were shorter in comparison with the control group(P<0.05),and the frequency of defecation was more in comparison with the control group(P<0.05).The total effective rate of experimental group was higher in comparison with control group(P<0.05).The jaundice index,interleukin(IL)-6,C-reactive protein(CRP)and procalcitonin(PCT)levels after therapy of two groups were decreased in comparison with before therapy(P<0.05),and the experimental group was lower than the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the experimental group and the control group(P>0.05).Conclusion:Bifidobacterium combined with vitamin K1 in the therapy of children with jaundice has a significant curative effect,which has a good effect in improving the clinical symptoms and inflammatory response of children,and the therapeutic safety is good,it can provide reference for the clinical treatment of children with jaundice.

关 键 词：黄疸 新生儿 双歧杆菌 维生素K1 疗效 炎症指标 

分 类 号：R722.17[医药卫生—儿科] R575[医药卫生—临床医学]