单纯肥胖患儿血清25-(OH)-D水平与营养代谢指标的相关性  

Correlation between serum 25-(OH)-D level and nutrition metabolism in children with simple obesity

作　　者：夏汝杰[1] 范佳鑫 陶蜀杭 XIA Ru-jie;FAN Jia-xin;TAO Shu-hang(Department of Laboratory Medicine,Chengdu Second People s Hospital,Chengdu 610000,Sichuan,China)

机构地区：[1]成都市第二人民医院检验科,四川成都610000

出　　处：《川北医学院学报》2024年第6期791-794,共4页Journal of North Sichuan Medical College

基　　金：四川省医学会课题项目(Q22084)。

摘　　要：目的:探讨单纯肥胖患儿血清25羟维生素D[25-(OH)-D]水平与营养代谢指标的相关性。方法:纳入107例单纯性肥胖的患儿为观察组;同期40名健康儿童为对照组。收集两组对象一般资料,检测并比较血清25-(OH)-D、糖代谢[空腹血糖(FPG)、糖化血红蛋白(HbAlc)]、脂代谢[总胆固醇(TC)、高/低密度脂蛋白胆固醇(H/LDL-C)、甘油三酯(TG)]及营养代谢[白蛋白(ALB)、前白蛋白(PA)、铁蛋白(Fer)]水平,采用Pearson相关性分析血清25-(OH)-D与各指标间相关性。结果:观察组患儿体质量、BMI、腰围、臀围、腰臀比、血清FPG、TC、TG及ALB、PA、Fer水平均明显高于对照组(P<0.05),25-(OH)-D低于对照组(P<0.05)。相关性分析显示,单纯性肥胖儿童血清25-(OH)-D水平与体质量、BMI、腰围、臀围、腰臀比、FPG、ALB、PA、Fer均呈负相关关系(P<0.05)。结论:单纯性肥胖儿童血清25-(OH)-D水平显著低于正常体质量儿童,其浓度与其体格、FPG及ALB、PA、Fer密切相关,临床应重视。Objective:To explore the correlation between serum 25-hydroxyvitamin D[25-(OH)-D]level and nutrition metabolism in children with simple obesity.Methods:107 children with simple obesity were selected as the observation group,and 40 healthy children during the same period were selected as the control group.Demographic data of the two groups were collected.The levels of serum 25-(OH)-D,glucose metabolism indicators[fasting plasma glucose(FPG),glycosylated hemoglobin(HbAlc)],lipid metabolism indicators[total cholesterol(TC),high/low density lipoprotein cholesterol(H/LDL-C),triglyceride(TG)],and nutrition metabolism indicators[albumin(ALB),prealbumin(PA),ferritin(Fer)]were measured and compared.The correlation between serum 25-(OH)-D and each indicator was analyzed by Pearson correlation analysis.Results:Compared with the control group,the observation group showed a increase in weight,BMI,waist circumference,hip circumference,waist and hip circumference,serum FPG,TC,TG,ALB,PA,Fer levels,and a decrease in 25-(OH)-D levels(P<0.05).Correlation analysis showed that serum 25-(OH)-D level was negatively correlated with weight,BMI,waist circumference,hip circumference,waist-to-hip ratio,FPG,ALB,PA and Fer(P<0.05).Conclusion:Serum 25-(OH)-D level in children with simple obesity is significantly lower than that in children with normal weight,and its concentration is closely related to the children s physique,FPG,ALB,PA and Fer.

关 键 词：单纯性肥胖 儿童 25羟维生素D 营养代谢 

分 类 号：R473.32[医药卫生—护理学]