微波与离子液体协同催化高效合成1,4-二氢吡啶类化合物  

Efficient synthesis of 1,4-dihydropyridines catalyzed by microwave and ionic liquids

作　　者：康丽琴 倪宇薇 丁华敏 KANG Liqin;NI Yuwei;DING Huamin(School of Chemical and Environmental Engineering,Shanghai Institute of Technology,Shanghai 201418,China)

机构地区：[1]上海应用技术大学化学与环境工程学院,上海201418

出　　处：《应用技术学报》2024年第2期185-189,共5页Journal of Technology

摘　　要：在以吡啶为母体的离子液体和微波辐射协同催化下,以醋酸铵、间硝基苯甲醛和3-氧代-N-苯基丁酰胺为原料,通过Hantzsch反应一锅合成2,6-二甲基-4-3ˊ-硝基苯基-N3,N5-二苯基-3,5-二甲酰胺-1,4-二氢吡啶化合物,产物结构通过1H-NMR表征进行了确认。与文献中描述的方法相比,该方法具有反应过程简单、反应时间短、收率高、催化剂易重复使用等优点。2,6-dimethyl-4-3ˊ-nitrophenyl-N3,N5-diphenyl-3,5-diformamide dihydropyridine was synthesized from 3-nitrobenzaldehyde,3-oxygen-N-phenylbutanamide and ammonium acetate via Hantzsch reaction in the presence of ionic liquid with pyridine as the mother under microwave irradiation.The corresponding structure of the product is characterized by 1H-NMR.Compared by the methods in the literature,this method has a simple reaction process,short reaction time,high yield,and easy reuse.

关 键 词：Hantzsch反应 离子液体 微波 一锅 

分 类 号：O626[理学—有机化学]