6-异丙基-3,4-二氢嘧啶类化合物的高效催化合成  

High efficiency catalytic synthesis of the 6-isopropyl-3,4-dihydropyrimidones

作　　者：陈晓霞 黄清俊 吴卓 CHEN Xiaoxia;HUANG Qingjun;WU Zhuo(School of Ecological Technology and Engineering,Shanghai Institute of Technology,Shanghai 201418,China;Shanghai Engineering Research Center of Green Fluoropharmaceutical Technology,Shanghai 201418,China)

机构地区：[1]上海应用技术大学生态技术与工程学院,上海201418 [2]上海绿色氟代制药工程技术研究中心,上海201418

出　　处：《应用技术学报》2024年第2期190-196,共7页Journal of Technology

摘　　要：开发了一种新型、简便的合成方法,在无溶剂条件下,以4,5-甲基-L-脯氨酸为催化剂,催化比吉内利反应(Biginelli reaction)高效合成6-异丙基-3,4-二氢嘧啶类化合物。反应条件温和,催化剂环保,产率优异(高达99%),可以获得广泛的具有显著生物活性的目标产物。A novel and simple catalytic methodology to highly efficient synthesis of the 6-isopropyl-3,4-dihydropyrimidines via Biginelli condensation using efficient,eco-friendly 4,5-methano-L-prolines as catalyst under solvent-free condition has been developed.A variety of compounds with excellent biological activity was obtained in good to excellent high yields(up to 99%)under mild conditions.

关 键 词：有机催化 BIGINELLI反应 6-异丙基-3 4-二氢嘧啶 4 5-甲基-L-脯氨酸 

分 类 号：O626[理学—有机化学]