用于诊断生长抑素受体阳性神经内分泌肿瘤的新药——^(68)Ga-DOTATOC  

^(68)Ga-DOTATOC,a new diagnostic agent for localization of somatostatin receptorp ositive neuroendocrine tumors

作　　者：赵思邈 陈超阳[1] 魏然 张玄龄 周颖[1,2] ZHAO Si-miao;CHEN Chao-yang;WEI Ran;ZHANG Xuan-ling;ZHOU Ying(Department of Pharmacy,Peking University First Hospital,Beijing 100034,China;Drug Clinical Trial Institution,Peking University First Hospital,Beijing 100034,China)

机构地区：[1]北京大学第一医院药剂科,北京100034 [2]北京大学第一医院药物临床试验机构,北京100034

出　　处：《中国临床药理学杂志》2024年第11期1654-1657,共4页The Chinese Journal of Clinical Pharmacology

摘　　要：^(68)Ga-DOTATOC是一种放射性诊断用药,用于成人和儿童患者生长抑素受体阳性神经内分泌肿瘤(NETs)的正电子发射断层扫描定位。^(68)Ga-DOTATOC可结合表达生长抑素受体(SSTRs)的细胞,包括过度表达SSTR2受体的恶性神经内分泌细胞。镓-68是一种放射性核素,用于正电子发射断层扫描,进而实现肿瘤诊断功能。现本文对^(68)Ga-DOTATOC的作用机制、药代动力学、用法用量、临床评价、安全性、特殊人群用药等进行综述。^(68)Ga-DOTATOC injection is a radiopharmaceutical agent for positron emission tomography localization of somatostatin receptor positive neuroendocrine tumors(NETs)in adult and pediatric patients.^(68)Ga-DOTATOC binds to cells that express somatostatin receptors(SSTRs),including malignant neuroendocrine cells that overexpress SSTR2 receptor.Gallium-68 is a radionuclide used in positron emission tomography for tumor diagnosis.This paper introduces its the mechanism of action,pharmacokinetics,usage and dosage,clinical evaluation,safety and use in specific populations.

关 键 词：^(68)Ga-DOTATOC 放射性诊断剂 生长抑素受体阳性神经内分泌肿瘤 

分 类 号：R981[医药卫生—药品]