用于术中肿瘤检测的光学成像剂——帕叶昔宁钠  

Pafolacianine,optical imaging agents for intraoperative tumor detection

作　　者：王钊 陈超阳[1] 魏然 张玄龄 胡晓娟 周颖[1,3] WANG Zhao;CHEN Chao-yang;WEI Ran;ZHANG Xuan-ling;HU Xiao-juan;ZHOU Ying(Department of Pharmacy,Peking University First Hospital,Beijing 100034,China;Pharmacy Department,Peking University First Hospital Ningxia Women and Children's Hospital,Yingchuan 750001,Ningxia Hui Autonomous Region,China;Drug Clinical Trial Institution,Peking University First Hospital,Beijing 100034,China)

机构地区：[1]北京大学第一医院药剂科,北京100034 [2]北京大学第一医院宁夏妇女儿童医院药剂科,宁夏回族自治区银川750001 [3]北京大学第一医院药物临床试验机构,北京100034

出　　处：《中国临床药理学杂志》2024年第11期1658-1660,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：帕叶昔宁钠是一种针对叶酸受体(FR)的荧光药物,用于成年卵巢癌患者,作为术中识别恶性病变的辅助手段。帕叶昔宁钠与表达FR的癌细胞结合,通过受体介导的内吞作用聚集在FR阳性的癌症组织中,可被近红外荧光成像系统激发,指导肿瘤的手术切除。本文对帕叶昔宁钠作用机制、药代动力学、临床研究、安全性等作一介绍。Pafolacianine is a fluorescent agent that specifically targets folate receptors, employed in the treatment of adult ovarian cancer patients to support the detection of malignant growths during surgical interventions. Pafolacianine binds to cancer cells expressing folate receptors, accumulating within folate-receptor-positive tumor tissue through receptor-mediated endocytosis. It can be excited by near-infrared fluorescence imaging, facilitating the surgical removal of tumors during procedures. This article gives an introduction to the mechanism of action, pharmacokinetics, clinical studies, and safety aspects of Pafolacianine.

关 键 词：帕叶昔宁钠 光学成像剂 卵巢癌 肺癌 

分 类 号：R981[医药卫生—药品]