用于核磁共振成像检查的放射性诊断新药——钆吡醇  

Gadopiclenol,a new radiological diagnostic drug used in magnetic resonance imaging

作　　者：郑璐 杨婷[1] 陈超阳[1] 魏然 张玄龄 邓靖中 周颖[1,3] ZHENG Lu;YANG Ting;CHEN Chao-yang;WEI Ran;ZHANG Xuan-ling;DENG Jing-zhong;ZHOU Ying(Department of Pharmacy,Peking University First Hospital,Bejing 100034,China;Department of Pharmacy,Peking University First Hospital Taiyuan Hospital,Taiyuan 030000,Shanxi Province,China;Drug Clinical Trial Institution,Peking University First Hospital,Bejing 100034,China)

机构地区：[1]北京大学第一医院药剂科,北京100034 [2]北京大学第一医院太原医院药剂科,山西太原030000 [3]北京大学第一医院药物临床试验机构,北京100034

出　　处：《中国临床药理学杂志》2024年第11期1661-1664,共4页The Chinese Journal of Clinical Pharmacology

摘　　要：钆吡醇是成人和2岁及以上儿科患者在采用核磁共振成像(MRI)探测和观察中枢神经系统(大脑、脊柱和相关组织)和身体(头颈、胸部、腹部、骨盆和肌肉骨骼系统)是否具有异常血管特性病变时使用的一种造影剂。钆吡醇是一种新型的大环钆基造影剂(GBCA),本文现从钆吡醇的分子结构、作用机制、药效学、药代动力学、临床研究和安全性等方面进行综述,以介绍该药的研究现状和已有成果。Gadopiclenol was used in adults and pediatric patients 2 years of age and older during magnetic resonance imaging(MRI)to detect and view lesions of the central nervous system(brain,spine,and associated tissues)and body(head and neck,chest,abdomen,pelvis,and musculoskeletal system)with abnormal vascular properties.Gadopiclenol is a new type of macrocyclic gadolinium-based contrast agent(GBCA).In this article,the molecular structure,principle of action,pharmacodynamics,pharmacokinetics,clinical studies,safety and other aspects of Gadopiclenol were reviewed,in order to introduce the current research status and existing achievements of Gadopiclenol.

关 键 词：钆吡醇 核磁共振成像 造影剂 大环钆基造影剂 

分 类 号：R981[医药卫生—药品]