缺氧诱导因子-1α在肿瘤中的病理机制及中药干预的研究现状  

Pathological mechanism of hypoxia-inducible factor-1α in tumours and the current status of research on Chinese medicine intervention

作　　者：刘瑜 张利英[1,2] 郝国雄 祁亚锋 徐倩 刘叶元 袁超 朱鹏 刘永琦 张志明[4] LIU Yu;ZHANG Li-ying;HAO Guo-xiong;QI Ya-feng;XU Qian;LIU Ye-yuan;YUAN Chao;ZHU Peng;LIU Yong-qi;ZHANG Zhi-ming(Key Laboratory of Molecular Medicine and Traditional Chinese Medicine Prevention and Control Research of Major Diseases in Gansu,Universities,Gansu University of Traditional Chinese Medicine,Lanzhou 730000,Gansu Province,China;Gansu Institute of Cardiovascular Disease,Lanzhou 730000,Gansu Province,China;Endocrinology Department,Beijing Fengtai Hospital ofI ntegrative Medicine,Bejing 100071,China;Cancer Department,Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730000,Gansu Province,China)

机构地区：[1]甘肃中医药大学甘肃省高校重大疾病分子医学与中医药防治研究重点实验室,甘肃兰州730000 [2]甘肃省心血管病研究所,甘肃兰州730000 [3]北京市丰台区中西医结合医院内分泌科,北京100071 [4]甘肃省中医院肿瘤科,甘肃兰州730000

出　　处：《中国临床药理学杂志》2024年第11期1670-1674,共5页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金资助项目(82260882);高端人才承担省级科技计划基金(“长江学者奖励计划”)资助项目(22ZD1FA001)。

摘　　要：中药可调控缺氧诱导因子-1α(HIF-1α)信号通路,主要通过抑制肿瘤血管生成、糖酵解、上皮间质转化等病理过程,从而减缓肿瘤进展。本文从HIF-1α及相关因子着手,综述其在肿瘤的病理机制及中药干预研究,旨在为中药治疗肿瘤提供理论参考。Traditional Chinese medicine can regulate the hypoxia-inducible factor-1α(HIF-1α) signalling pathway and slow down tumour progression mainly by inhibiting tumour angiogenesis, glycolysis, epithelial mesenchymal transition and other pathological processes. This paper, starting from HIF-1α and related factors, reviews its pathological mechanism in tumours and the research of traditional Chinese medicine interventions with the aim of providing theoretical references for the treatment of tumours with traditional Chinese medicine.

关 键 词：中药 缺氧诱导因子-1Α 肿瘤 缺氧 

分 类 号：R28[医药卫生—中药学]