针灸辅助改善冻融胚胎移植疗效的网状meta分析  

Effect of acupuncture and moxibustion as the adjuvant therapy on frozen-thawed embryo transfer:A network meta-analysis

作　　者：罗敏辉 谭艳 左耀辰 石文英[2] 王鑫 章薇[2] Min-hui LUO;Yan TAN;Yao-chen ZUO;Wen-ying SHI;Xin WANG;Wei ZHANG(Hunan University of Chinese Medicine,Changsha,410208,China;The First Hospital of Hunan University of Chinese Medicine,Changsha,410007,China)

机构地区：[1]湖南中医药大学,长沙410208 [2]湖南中医药大学第一附属医院,长沙410007

出　　处：《World Journal of Acupuncture-Moxibustion》2024年第2期103-116,共14页世界针灸杂志（英文版）

基　　金：Supported by TCM Evidence-Based Capacity Construction Project,National Administration of Traditional Chinese Medicine,2019:2019XZZX-ZJ007;National Key Research and Development Program:2019YFC1709104。

摘　　要：Objective:To evaluate the clinical effect of acupuncture-moxibustion as the adjuvant therapy on frozenthawed embryo transfer(FET)using network meta-analysis.Methods:In PubMed,Embase,Cochrane Library,Chinese National Knowledge Infrastructure(CNKI),Wanfang database(WanFang),VIP database and Chinese Biomedical Literature Database(SinoMed),the randomized controlled trials(RCTs)of the adjuvant therapy of acupuncture-moxibustion for FET were retrieved,from database inception to April 1,2021.Cochrane risk of bias assessment tool was used to screen and evaluate the quality of the included studies,and RevMan 5.3,GeMTC0.14.3 and Stata16.0 software were adopted to complete the network meta-analysis.Results:Twenty-nine RCTs comprising 2880 patients were finally included,involving 17 interventions and 4 outcome measures.The results of network meta-analysis showed that the top three therapies under each outcome based on the magnitude of SUCRA values were:(1)Clinical pregnancy rate(CPR,%):"transcutaneous electrical acupoint stimulation+herbal medicine"(76.4),"moxibustion+herbal medicine"(74.7),"acupuncture+moxibustion"(73.3);(2)Biochemical pregnancy rate(BPR):"moxibustion+herbal medicine"(89.3),"acupuncture+moxibustion"(82.1),"acupuncture+herbal medicine"(78.7);(3)Endometrial thickness:"acupoint injection+Western medicine"(87.2),auricular therapy(76.8),"acupuncture+herbal medicine"(73.5);(4)Type A endometrial morphology rate:"acupoint injection+Western medicine"(78.3),"moxibustion+herbal medicine"(58.0)and"acupuncture+moxibustion"(52.6).Conclusion:The combined treatment of acupuncture-moxibustion was superior to single therapy for FET patients.The combined therapy of transcutaneous electrical acupoint stimulation and herbal medicine had the best effect for improving CPR,"moxibustion+herbal medicine"obtained the best average comprehensive effect,and"acupoint injection+Western medicine"was conductive to ameliorate the endome trial thickness and morphology.Due to the limitations of existing studies,more high-quality RCTs are neede

关 键 词：ACUPUNCTURE MOXIBUSTION Frozen-thawed embryotransfer Pregnancy rate Endometriumthickness Endometrial morphology Networkmeta-analysis 

分 类 号：R246.3[医药卫生—针灸推拿学] G353.1[医药卫生—中医临床基础]