针刺治疗屈光参差性弱视:一项随机对照试验及其潜在起效机制  

Effect of acupuncture for anisometropic amblyopia:A randomized clinical trial and potential mechanism

作　　者：马翠 贾静 叶钰娟 孙燕[2] 严兴科 Cui MA;Jing JIA;Yu-juan YE;Yan SUN;Xing-ke YAN(College of Acupuncture-Moxibustion and Tuina,Gansu University of Chinese Medicine,Lanzhou 730000,China;Gansu Provincial Hospital Rehabilitation Center,Lanzhou 73000,China)

机构地区：[1]甘肃中医药大学针灸推拿学院,兰州730000 [2]甘肃省康复中心医院,兰州730000

出　　处：《World Journal of Acupuncture-Moxibustion》2024年第2期147-155,共9页世界针灸杂志（英文版）

基　　金：Supported by Provincial Key Talent Project of Gansu Province:[2023]20;National Natural Science Foundation of China:82160935,81860879;2022 Doctoral Tutor Project of Chinese Medicine First Level Discipline"Qi Huang Ying Cai"Tutor Special Fund:ZYXKBD-202208;2021 Gansu Province Higher Education Innovation Fund Project:2021A-087;Gansu University of Traditional Chinese Medicine Science Research and Innovation Fund Project:2022KCYB-8。

摘　　要：Objective:To evaluate the effect of acupuncture on anisometropic amblyopia(AA)and explore its potential mechanism for children with AA.Methods:Seventy-six children with monocular AA were randomized into a conventional treatment group and a combined treatment group of acupuncture and conventional treatment,with 38 patients in each group.In the conventional treatment group,on the base of patching regimen,the red flashing,grating and visual stimulation were delivered.Each approach lasted for 5 min per session and was given once every two days,three times a week,for 4 consecutive weeks.In the acupuncture-combined treatment group,on the base of the regimen of conventional treatment group,acupuncture was applied to Jingming(BL1),Cuanzhu(BL2),Fengchi(GB20)and Guangming(GB37),with needles retained for 20 min per session,once every two days,three times of intervention a week and for 4 consecutive weeks.Before and after treatment,the best corrected vision acuity(BCVA)was observed to evaluate the clinical effect in the two groups.Before treatment started,15 patients with AA on left side were randomized selected from each group and the resting-state functional magnetic resonance imaging(rs-fMRI)was operated before and after treatment.Simultaneously,eight healthy children with normal visual acuity were recruited to be the normal control group and received one-time rs-fMRI scanning.Based on the activation likelihood estimation(ALE),the visual"what"pathway network was constructed.By analyzing the amplitude of low frequency fluctuation(ALFF)and the regional homogeneity(ReHo),the differences in the regional autonomous function activities in the key brain areas of the"what"pathway were compared among the three groups.Results:(1)Clinical effect:After treatment,BCVA was(0.6[0.5,0.6]),higher than that(0.4[0.3,0.5])before treatment,presenting the statistical difference(P<0.05)in the conventional treatment group.BCVA was(0.6[0.6,0.8]),higher than that(0.4[0.4,0.5])before treatment,presenting the statistical difference(P<0.05)in the acu

关 键 词：Anisometropic amblyopia ACUPUNCTURE Resting-state fMRI Visual"what"pathway Amplitude of low frequency fluctuation Regional homogeneity 

分 类 号：R246.82[医药卫生—针灸推拿学]