百令胶囊治疗早期腹膜透析患者的疗效分析  

Efficacy of Bailing Capsule on Early Peritoneal Dialysis Patients

作　　者：何川鄂[1] 饶毅峰[1] 宋志霞[1] 杜京涛[1] 李玉枝 He Chuan'e;Rao Yifeng;Song Zhixia;Du Jingtao;Li Yuzhi(Department of Nephrology,Yichang Central People's Hospital,The First College of Clinical Medical Science,China Three Gorges University,Yichang 443003,China)

机构地区：[1]三峡大学第一临床医学院[宜昌市中心人民医院]肾病内科,湖北宜昌443003

出　　处：《巴楚医学》2024年第2期36-41,共6页Bachu Medical Journal

基　　金：湖北省自然科学基金项目(No:Z2021307,2021CFB379)。

摘　　要：目的:研究百令胶囊治疗早期腹膜透析(EPD)患者的疗效。方法:选取2019年1月—2020年12月就诊于宜昌市中心人民医院的100例EPD患者,采用随机数字表法将其分成两组,对照组患者接受EPD治疗(n=50),观察组患者行EPD治疗的同时加服百令胶囊(n=50)。对比研究两组患者治疗三个月后的肾功能、营养状况、微炎症因子及氧化应激指标。结果:在改善肾功能方面,观察组患者残余肾功能(RRF)、24 h尿量及24 h超滤量均显著高于对照组(均P<0.05);在营养状态方面,观察组患者血清白蛋白(Alb)、前白蛋白(PA)、转铁蛋白(TRF)及血红蛋白(Hb)明显高于对照组(均P<0.05),且观察组患者的改进主观全面营养评定量表(MQSGA)明显降低(10.02±1.05分vs 12.54±2.20分,P<0.05);在微炎症指标方面,观察组血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)、血管内皮生长因子(VEGF)、转化生长因子-β1(TGF-β1)水平均明显低于对照组(均P<0.05);在氧化应激方面,观察组患者血清中丙二醛(MDA)、同型半胱氨酸(Hcy)含量较对照组均显著降低,超氧化物歧化酶(SOD)活力明显高于对照组(均P<0.05);两组患者不良反应无明显差异(P>0.05)。结论:百令胶囊可有效缓解EPD患者氧化应激反应、减轻微炎症状态,改善营养不良,提高患者的肾功能。Objective:To study the efficacy of Bailing Capsule in the treatment of early peritoneal dialysis(EPD)patients.Methods:A total of 100 EPD patients treated in Yichang Central People's Hospital from January 2019 to December 2020 were randomly divided into two groups using a random number table method.The control group received EPD treatment(n=50),while the observation group received EPD treatment plus Bailing Capsule(n=50).Renal function,nutritional status,micro-inflammatory factors,and oxidative stress indicators were compared between the two groups after three months of treatment.Results:In terms of improving renal function,the residual renal function(RRF),24-hour urine volume,and 24-hour ultrafiltration volume were significantly higher in the observation group than in the control group(all P<0.05).In terms of nutritional status,serum albumin(Alb),prealbumin(PA),transferrin(TRF),and hemoglobin(Hb)were significantly higher in the observation group than in the control group(all P<0.05),and the modified quantitative subjective global assessment(MQSGA)was significantly lower in the observation group(10.02±1.05 vs 12.54±2.20,P<0.05).In terms of micro-inflammatory markers,serum levels of interleukin 6(IL-6),tumor necrosis factor-α(TNF-α),hypersensitive C-reactive protein(hs-CRP),vascular endothelial growth factor(VEGF),and transforming growth factor-β1(TGF-β1)were significantly lower in the observation group than in the control group(all P<0.05).In terms of oxidative stress,serum levels of malondialdehyde(MDA)and homocysteine(Hcy)were significantly lower in the observation group than in the control group,while superoxide dismutase(SOD)activity was significantly higher in the observation group(all P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion:Bailing Capsule can effectively alleviate oxidative stress and micro-inflammatory status,improve malnutrition,and enhance renal function in EPD patients.

关 键 词：百令胶囊 早期腹膜透析 残余肾功能 微炎症因子 氧化应激 

分 类 号：R692.5[医药卫生—泌尿科学]