血清低水平乙肝病毒表面抗原的临床意义分析  

Clinical Significance of Low Serum Levels of Hepatitis B Surface Antigen

作　　者：龚敏莉 罗微[2] 毕月 Gong Minli;Luo Wei;Bi Yue(Department of Clinical Laboratory,Ningbo Zhenhai People's Hospital Group,Ningbo 315200,China;Department of Clinical Laboratory General Hospital of Tianjin Medical University,Tianjin 300052,China)

机构地区：[1]宁波市镇海区人民医院医学检验科,浙江宁波315200 [2]天津医科大学总医院医学检验科,天津300052

出　　处：《巴楚医学》2024年第2期86-91,共6页Bachu Medical Journal

基　　金：浙江省医药卫生科技计划项目(No:2019KY627);宁波市镇海区公益类项目(No:2019S003)。

摘　　要：目的:探讨血清中低水平乙肝病毒表面抗原(HBsAg)与乙肝病毒(HBV)DNA载量及肝功能指标的关系。方法:选取2020年6月—2021年12月在宁波市镇海区人民医院就诊的低水平HBsAg患者408例,检测所有纳入患者的乙肝病毒表面抗体(抗-HBs)、乙肝病毒e抗原(HBeAg)、乙肝病毒e抗体(抗-HBe)及乙肝病毒核心抗体(抗-HBc)、HBV DNA载量检测及相关肝功能指标。结果:408例低水平HBsAg患者中,抗-HBe和抗-HBc均为阳性,且抗-HBs和HBeAg均为阴性的患者占比最高,共360例(88.24%);HBV DNA阳性共82例(20.10%),不同浓度HBsAg患者HBV DNA阳性率差异有统计学意义(P=0.041),HBsAg浓度在31~40 COI时,HBV DNA的阳性率最高(30.00%);不同浓度HBsAg时HBV DNA载量差异无统计学意义(P>0.05);不同浓度HBsAg及HBV DNA对应的肝功能检测结果差异无统计学意义(均P>0.05)。结论:低水平HBsAg患者中,抗-HBe和抗-HBc均为阳性,且抗-HBs和HBeAg均为阴性的患者占比最高;HBsAg浓度不同时,HBV DNA阳性率也不同,但并不影响HBV DNA载量;HBsAg浓度及HBV DNA载量不同并不影响患者的肝功能。Objective:To investigate the relationship between low level of hepatitis B virus surface antigen(HBsAg)in serum,HBV DNA load and liver function index.Methods:A total of 408 patients with low level HBsAg treated in Zhenhai District People's Hospital of Ningbo City from June 2020 to December 2021 were selected.Hepatitis B virus surface antibody(anti-HBs),hepatitis B virus e antigen(HBeAg),hepatitis B virus e antibody(anti-HBe)and hepatitis B virus core antibody(anti-HBc),HBV DNA load and liver function indicators were detected in all enrolled patients.Results:Among 408 patients with low level HBsAg,patients with positive anti-HBe and anti-HBc,and negative anti-HBs and HBeAg,accounted for the highest proportion(88.24%).A total of 82 cases(20.10%)were HBV DNA positive,and there was a significant difference in HBV DNA positive rate at different concentrations of HBsAg(P=0.041).When HBsAg concentration was between 31 and 40 COI,the HBV DNA positive rate was the highest(30.00%).There was no significant difference in HBV DNA load among different concentrations of HBsAg(P>0.05).There was no significant difference in liver function of different concentrations of HBsAg and HBV DNA(both P>0.05).Conclusion:In patients with low level HBsAg,the proportion of patients with positive anti-HBe/anti-HBc and negative anti-HBs/HBeAg is the highest.The positive rate of HBV DNA varies with different concentration of HBsAg,but it has no impact on HBV DNA load.HBsAg concentration and HBV DNA load have no impact on the liver function of low level HBsAg patients.

关 键 词：乙肝病毒 乙肝病毒表面抗原 HBV DNA载量 肝功能 

分 类 号：R512.6[医药卫生—内科学]