补阳还五汤联合艾灸治疗晚期胃癌血液高凝状态  

Treatment of Blood Hypercoagulability in Advanced Gastric Cancer with Buyang Huanwu Decoction Combined with Moxibustion

作　　者：毕俊芳[1] 王永欣 BI Jun-fang;WANG Yong-xin(Shijiazhuang Hospital of Traditional Chinese Medicine of Hebei Province,Shijiazhuang,050051,China;Beijing Tongrentang Shijiazhuang Traditional Chinese Medicine Hospital,Shijiazhuang,050011,China)

机构地区：[1]河北省石家庄市中医院,石家庄050051 [2]北京同仁堂石家庄中医医院,石家庄050011

出　　处：《河北中医药学报》2024年第3期12-16,共5页Journal of Hebei Traditional Chinese Medicine and Pharmacology

基　　金：河北省中医药管理局科研计划项目:No.2019438。

摘　　要：目的:探究补阳还五汤联合艾灸对晚期胃癌血液高凝状态(hypercoagulable state,HCS)的影响。方法:将70例符合纳入标准的晚期胃癌患者,随机分为治疗组和对照组,每组各35例,2组均予抗肿瘤及支持对症治疗,治疗组同时予补阳还五汤联合艾灸,21 d为1个周期,均治疗2个周期。比较2组治疗前后凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、D-二聚体(D-D)、血小板(PLT)指标,评估中医证候及生活质量[采用卡氏(KPS)评分]改善情况。结果:治疗组治疗后PT、APTT值延长,FIB、PLT、D-D值降低,组间及组内比较均有统计学意义(P<0.05);治疗组治疗后中医证候改善,疗效优于对照组(Z=-2.572,P<0.05);治疗后,治疗组KPS评分改善,疗效优于对照组(Z=-2.262,P<0.05)。结论:补阳还五汤联合艾灸可减轻晚期胃癌HCS,对气虚血瘀证候及生活质量的改善亦有助益,具有较好的临床疗效。Objective:To explore the effect of Buyang Huanwu Decoction(BYHWD)combined with moxibustion on blood hypercoagulability in advanced gastric cancer.Methods:A total of 70 patients who met the inclusion criteria were randomly divided into a treatment group and a control group,with 35 patients in each group.Both groups received anti-tumor and supportive symptomatic treatment,while the treatment group also received BYHWD combined with moxibustion.The treatment cycle was 21 days,and both groups were treated for 2 cycles.The changes in prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(FIB),D-dimer(D-D),and platelet(PLT)levels before and after treatment were compared.Additionally,improvements in Chinese medicine symptoms and quality of life(assessed using the Karnofsky Performance Scale,KPS)were evaluated.Results:After treatment,the PT and APTT values in the treatment group increased,while the FIB,PLT,and D-D values decreased.Both the inter-group and intra-group comparisons showed statistical significance(P<0.05).The improvement in Chinese medicine symptoms in the treatment group was better than that in the control group(Z=-2.572,P<0.05).Additionally,after treatment,the KPS score in the treatment group improved,and the therapeutic effect was better than that in the control group(Z=-2.262,P<0.05).Conclusion:The combination of BYHWD and moxibustion can alleviate the hypercoagulable state of blood in patients with advanced gastric cancer,and also contributes to improving qi deficiency and blood stasis syndromes as well as the quality of life,demonstrating good clinical efficacy.

关 键 词：补阳还五汤 艾灸 胃癌 高凝状态 

分 类 号：R273[医药卫生—中西医结合]