腺样体肥大患儿腺样体组织中半胱氨酰白三烯受体1的表达及其影响因素  

Expression of cysteinyl leukotriene receptor 1 in adenoid tissue of children with adenoid hypertrophy and its influencing factors

作　　者：张冰 管仁政[1] 金蓉[1] 林荣军[1] 王学海[2] ZHANG Bing;GUAN Renzheng;JIN Rong;LIN Rongjun;WANG Xuehai(Department of Pediatrics,The Affiliated Hospital of Qingdao University,Qingdao 266003,China)

机构地区：[1]青岛大学附属医院儿科,山东青岛266003 [2]威海市立医院耳鼻咽喉科

出　　处：《精准医学杂志》2024年第3期267-270,共4页Journal of Precision Medicine

基　　金：山东省中医药科技项目(M2022227)。

摘　　要：目的分析半胱氨酰白三烯受体1(CysLTR1)在腺样体肥大(adenoid hypertrophy,AH)患儿腺样体组织中的表达特点,探究CysLTR1在AH形成中的作用机制及CysLTR1表达的影响因素。方法选取2020年10月1日—2021年10月1日在威海市立医院耳鼻咽喉科行腺样体切除术患儿71例,对其切除标本行CysLTR1免疫组化染色,根据染色结果分为CysLTR1高表达组及低表达组。收集两组患儿性别、年龄、腺样体肥大程度、有无变应性鼻炎、有无其他合并症(分泌性中耳炎、慢性鼻窦炎、呼吸睡眠暂停综合征)等资料并进行比较,通过多因素logistic回归分析影响AH患儿CysLTR1表达的危险因素。结果免疫组化染色结果显示,CysLTR1在71例AH患儿腺样体组织中均有表达,高表达组患儿的腺样体肥大程度、有无变应性鼻炎及有无其他合并症与低表达组相比差异有显著性(χ^(2)=9.003~49.196,P<0.05)。多因素logistic回归分析显示,重度腺样体肥大、变应性鼻炎以及有其他合并症均为影响AH患儿CysLTR1表达的独立危险因素(P<0.05)。结论CysLTR1在AH患儿腺样体组织中表达与腺样体肥大程度、有无变应性鼻炎及其他合并症相关,且上述3指标为CysLTR1高表达的独立危险因素。Objective To investigate the expression characteristics of cysteamine leukotriene receptor 1(CysLTR1)in the adenoid tissue of children with adenoid hypertrophy(AH),as well as the mechanism of action of CysLTR1 in the formation of AH and the influencing factors for CysLTR1 expression.Methods A total of 71 children who underwent adenoidectomy in Department of Otolaryngology,Weihai Municipal Hospital,from October 1,2020 to October 1,2021 were enrolled.Immunohistochemical staining was performed for CysLTR1 in the resected specimens,and according to the results of staining,the children were divided into high CysLTR1 expression group and low CysLTR1 expression group.The two groups were compared in terms of the data including sex,age,degree of adenoid hypertrophy,presence or absence of allergic rhinitis,and presence or absence of other comorbidities(secretory otitis media,chronic sinusitis,and sleep apnea syndrome),and a multivariate logistic regression analysis was used to identify the influencing factors for the expression of CysLTR1 in children with AH.Results Immunohistochemistry showed that CysLTR1 was expressed in the adenoid tissue of all 71 children with AH,and there were significant differences between the high and low expression groups in the degree of adenoid hypertrophy,the presence or absence of allergic rhinitis,and the presence or absence of other comorbidities(χ^(2)=9.003-49.196,P<0.05).The logistic regression analysis showed that the severe of adenoid hypertrophy,the presence of allergic rhinitis,and the presence of other comorbidities were independent risk factors for the expression of CysLTR1 in children with AH(P<0.05).Conclusion The expression of CysLTR1 in adenoid tissue of children with AH is associated with the degree of adenoid hypertrophy,the presence or absence of allergic rhinitis,and the presence or absence of other comorbidities,and these three indices are independent risk factors for the high expression of CysLTR1.

关 键 词：鼻炎 变应性 季节性 增殖腺 肥大 受体 白三烯 免疫组织化学 因素分析 统计学 

分 类 号：R766.3[医药卫生—耳鼻咽喉科]