生物钟紊乱对2型炎症变应性疾病的影响研究  

Research on the impact of type 2 inflammatory allergicdiseases by circadian rhythm disorders

作　　者：李瀚雄 程冯丽 祁雪萍[1] 王艳杰 安云芳[1] 赵长青[1] LI Hanxiong;CHENG Fengli;QI Xueping;WANG Yanjie;AN Yunfang;ZHAO Changqing(Department of Otorhinolaryngology Head and Neck Surgery,the Second Hospital of Shanxi Medical University,Key Research Laboratory of Airway Neuroimmunology of Shanxi Province,Taiyuan 030001,China)

机构地区：[1]山西医科大学第二医院耳鼻咽喉头颈外科,山西省气道炎性疾病神经免疫重点培育实验室,山西太原030001

出　　处：《中国耳鼻咽喉颅底外科杂志》2024年第3期116-120,共5页Chinese Journal of Otorhinolaryngology-skull Base Surgery

基　　金：国家自然科学基金面上项目(81670914、81870707、82171119、82171120);国家自然科学基金青年科学基金项目(82201263)。

摘　　要：生物钟是机体为适应外界环境周期性变化而进化出的内在机制。流行病学研究发现生物钟紊乱(CRD)是变应性疾病发病的重要诱因,其可能通过影响黏膜(或皮肤)屏障及系统免疫反应,进而改变靶器官的生理病理活动,通过药物或非药物干预可缓解变应性疾病的进展。本文聚焦于CRD在2型炎症变应性疾病中的作用,重点探讨CRD对以变应性鼻炎(AR)、哮喘、特应性皮炎、食物过敏为代表的2型炎症变应性疾病的影响,并试图从生物钟角度探讨2型炎症变应性疾病的治疗新策略。The circadian rhythm is an internal mechanism that evolved in organisms to adapt to periodic changes in the external environment.Epidemiological studies have found that circadian rhythm disorders(CRD)is an important cause of allergic diseases.It may affect the mucosal(or skin)barrier and the systemic immune response,thereby altering the physiological and/or pathological activities of target organs.The progression of allergic diseases can be alleviated through pharmacological or non-pharmacological interventions.This paper focuses on the role of CRD in type 2 inflammatory allergic diseases,particularly on the influence of CRD on type 2 inflammatory allergic diseases represented by allergic rhinitis,asthma,atopic dermatitis,and food allergy.It attempts to explore new treatment strategies for type 2 inflammatory allergic diseases from the perspective of the biological clock.

关 键 词：变态反应 2型炎症反应 生物钟紊乱 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]