真菌发酵对中药化学成分的转化及应用研究进展  

Research progress on transformation and application of chemical components of traditional Chinese medicine by fungal fermentation

作　　者：赖晓微 邓可众[1] 罗梦甜 刘佳 李楠 熊英[1] LAI Xiaowei;DENG Kezhong;LUO Mengtian;LIU Jia;LI Nan;XIONG Ying(College of Pharmacy,Jiangxi University of Chinese Medicine,Nanchang 330004,China)

机构地区：[1]江西中医药大学药学院,江西南昌330004

出　　处：《中国酿造》2024年第6期21-26,共6页China Brewing

基　　金：江西中医药大学研究生创新专项资金项目(No.JZYC22S61);国家自然科学基金项目(No.81260621)。

摘　　要：真菌发酵可以使中药化学成分发生糖基化、羟基化、甲基化等多种化学反应,并产生丰富的次生代谢产物,具有效率高、条件温和、选择性强、不污染环境、反应类型多等优势,但发酵过程的稳定性和可控性一直是个难题。该文概括了中药发酵技术及常用于发酵中药的真菌,综述了中药化学成分(黄酮、生物碱、甾体、萜类、醌类、苯丙素)的转化机制,并总结了真菌发酵中药常见菌种在中药成分转化中的应用,为后续合理利用真菌进行中药成分研究与开发提供参考依据。Fungal fermentation can cause a variety of chemical reactions such as glycosylation,hydroxylation and methylation of the chemical components of traditional Chinese medicine,and produce abundant secondary metabolites.Fungal fermentation has the advantages of high efficiency,mild conditions,strong selectivity,no pollution to the environment,and multiple reaction types,but the stability and controllability of the fermentation process have always been a problem.In this paper,the fermentation technology of traditional Chinese medicine and fungi commonly used in the fermentation were summarized,the transformation mechanism of traditional Chinese medicine chemical components(flavonoids,alkaloids,steroids,terpenoids,quinones,phenylpropanoids)was reviewed,and the application of common fungi in the transformation of traditional Chinese medicine components was summarized,so as to provide references for the subsequent research and development of traditional Chinese medicine components with the rational use of fungi.

关 键 词：真菌 发酵 中药化学成分 转化机制 应用 

分 类 号：R284[医药卫生—中药学] TS205.5[医药卫生—中医学]