日本脑炎病毒免疫逃逸分子机制研究进展  

Advances in Research Progress on the Molecular Mechanisms of Immune Escape of Japanese Encephalitis Virus

作　　者：何松 汤德元[1] 曾智勇[1] 王彬[1] 黄涛[1] 毛茵茗 周飘 廖正波 陈旭 袁盛林 胡雯雯 周敏 HE Song;TANG Deyuan;ZENG Zhiyong;WANG Bin;HUANG Tao;MAO Yinming;ZHOU Piao;LIAO Zhengbo;CHEN Xu;YUAN Shenglin;HU Wenwen;ZHOU Min(College of Animal Science,Guizhou University,Guiyang,Guizhou 550025,China)

机构地区：[1]贵州大学动物科学学院,贵阳550025

出　　处：《畜牧兽医学报》2024年第6期2368-2378,共11页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：贵州大学重点项目(黔科合平台人才[2018]5781-8);国家自然科学基金(31860716)。

摘　　要：日本脑炎(Japanese encephalitis, JE)是由日本脑炎病毒(Japanese encephalitis virus, JEV)引起的一种蚊媒性人兽共患传染病,虽然已有商品化疫苗,但疫苗的预防具有一定的局限性且至今尚无有效药物治疗,一旦暴发将威胁人们的生命健康和公共安全,造成重大经济损失。JEV含有数量众多具有免疫逃逸功能的编码蛋白,这些蛋白逃逸宿主免疫功能的机制多样且复杂,但其机制仍不完全清楚。同时,JEV复杂的免疫逃逸机制可能是阻碍疫苗免疫保护效果的关键因素。因此,本文主要对JEV通过抑制干扰素反应,调节细胞凋亡、焦亡、自噬及宿主miRNA等多种途径逃逸机体先天免疫和适应性免疫机制进行概述,以期为JEV致病机理的研究和疫苗研发提供思路与理论基础。Japanese encephalitis(JE)is a mosquito-borne animal disease caused by Japanese encephalitis virus(JEV),although there are commercially vaccines are availabe,however,the prevention of vaccines has certain limitations and there is no effective drug treatment so far,and once the outbreak will threaten occurs,people′s life and health and as well as the public safety will be threatened,thus resulting in significant economic losses.JEV contains a large number of encoded proteins with immune escape function.The mechanism of these proteins escaping host immune function is diverse and complex,and the mechanism is still not fully understood of which still remains unclear.At the same time,the complex immune escape mechanism of JEV may be the key factor hindering the immune protection effect of vaccine.Therefore,this paper mainly summarizes the mechanism of JEV escaping innate and adaptive immunity by inhibiting interferon response,regulating apoptosis,pyroptosis death,autophagy and host miRNA to provide ideas and theoretical basis for the research of JEV pathogenesis and vaccine development.

关 键 词：日本脑炎病毒 免疫逃逸 天然免疫 适应性免疫 

分 类 号：S852.65[农业科学—基础兽医学]