甘氨酸合成方法研究进展  

Research progress on synthesis method of glycine

作　　者：赵建平 李鸿雄 孙育滨 孙涛[4] 杨东元 王亚红 ZHAO Jianping;LI Hongxiong;SUN Yubin;SUN Tao;YANG Dongyuan;WANG Yahong(Shaanxi Yanchang Petroleum(Group)Co.,Ltd.,Xi’an 710065,Shaanxi,China;Shaanxi Yanchang Petroleum(Group)Co.,Ltd.&Dalian Institute of Chemical Physics Xi’an Clean Energy(Chemical Industry)Research Institute,Xi’an 710065,Shaanxi,China;Shaanxi Yanchang Xida Advanced Technology Research Institute Co.,Ltd.,Xi’an 710065,Shaanxi,China;School of Chemical Engineering,Northwest University,Xi’an 710069,Shaanxi,China;School of Chemical Engineering and Technology,Xi’an Jiaotong University,Xi’an 710065,Shaanxi,China;Xi’an Origin Chemical Technologies Co.,Ltd.,Xi’an 710043,Shaanxi,China)

机构地区：[1]陕西延长石油(集团)有限责任公司,陕西西安710065 [2]陕西延长石油(集团)有限责任公司大连化物所西安洁净能源(化工)研究院,陕西西安710065 [3]陕西延长西大先进技术研究院有限公司,陕西西安710065 [4]西北大学化工学院,陕西西安710069 [5]西安交通大学化工学院,陕西西安710065 [6]西安元创化工科技股份有限公司,陕西西安710043

出　　处：《低碳化学与化工》2024年第6期35-44,共10页Low-Carbon Chemistry and Chemical Engineering

基　　金：陕西省重点研发计划(2024GX-YBXM-508);陕西延长石油(集团)有限责任公司科技项目(ycsy2023ky-A-07)。

摘　　要：甘氨酸作为一种重要氨基酸,广泛应用于农药、医药、食品和饲料等领域,研究甘氨酸的合成方法具有重要的现实意义。综述了甘氨酸的化学合成方法(分别为氯乙酸氨解法、施特雷克法、氨基乙腈法、直接海因法、醇氨氧化法和羟基乙酸甲酯法)和生物合成方法(分别以氨基乙腈、二氧化碳+氨气为原料)的研究进展,深入分析和对比了各方法的优点与缺点,并对甘氨酸合成方法未来的发展进行了展望。As an important amino acid,glycine is widely used in pesticide,medicine,food and feed,etc.It is of great practical significance to study the synthesis method of glycine.The research progress of glycine chemical synthesis methods(chloro-acetic acid ammonolysis method,Strecker method,aminoacetonitrile method,hydantion method,alcohol ammoxidation method and methyl hydroxyacetate method,respectively)and biosynthesis methods(using aminoacetonitrile,carbon dioxide+ammonia as raw materials,respectively)were reviewed.The advantages and disadvantages of each method were analyzed and compared.The future development of glycine synthesis methods was also prospected.

关 键 词：甘氨酸 化学合成 生物合成 

分 类 号：TQ45[化学工程—农药化工]