基于AIE效应的内源性硫化氢荧光探针的研究进展  

Progress in the Study of Endogenous Hydrogen Sulfide Fluorescent Probes Based on AIE Effect

作　　者：刘冰弥[1,2,3] 宫达诚 田璐 生慧 LIU Bing-mi;GONG Da-cheng;TIAN Lu;SHENG Hui(School of Pharmacy,Liaoning University,Shenyang 110036,China;Institute of Forensic Sciences,Liaoning University,Shenyang 110036,China;Liaoning Key Laboratory of New Drug Development,Shenyang 110036,China;School of Physics,Liaoning University,Shenyang 110036,China)

机构地区：[1]辽宁大学药学院,辽宁沈阳110036 [2]辽宁大学司法鉴定研究院,辽宁沈阳110036 [3]辽宁新药研发重点实验室,辽宁沈阳110036 [4]辽宁大学物理学院,辽宁沈阳110036

出　　处：《辽宁大学学报（自然科学版）》2024年第2期130-140,共11页Journal of Liaoning University：Natural Sciences Edition

基　　金：国家自然科学基金青年科学基金项目(21807055);沈阳市自然科学基金项目(23-503-6-12)。

摘　　要：合理设计监测内源性硫化氢的荧光探针分子有助于充分了解其生理和病理功能.目前,在研的检测硫化氢的小分子荧光探针多存在聚集诱导猝灭效应,因此克服此缺陷的聚集诱导发光效应荧光探针的研究受到越来越多的关注.本文结合研究实践简要综述了近几年具有聚集诱导发光效应的化学反应型硫化氢活体成像荧光探针的研究进展及设计思想并进行展望,以期对该领域研究提供一些借鉴和思考.Rational design of fluorescent probe molecules for monitoring endogenous hydrogen sulfide(H 2S)can help to fully understand its physiological and pathological functions.Most of the small-molecule fluorescent probes currently under development for the detection of H 2S suffer from aggregation-caused quenching(ACQ)effect,and the study of aggregation-induced emission(AIE)probes that can overcome this deficiency has received increasing attention.In this paper,we briefly review the progress and design ideas of chemically reactive H 2S in vivo imaging fluorescent probes with AIE effect in recent years,with the aim of providing some reference and thoughts for research in this field.

关 键 词：内源性硫化氢 聚集诱导发光效应 聚集诱导猝灭效应 荧光探针 活体成像 

分 类 号：O657.3[理学—分析化学]