纳米递送系统用于肾纤维化诊疗的研究进展  

Research advances of nano-delivery system for diagnosing and treating renal fibrosis

作　　者：黎晨 邓针华 赵丽蓉 田弥 向玉玲 周本宏[1,2] Li Chen;Deng Zhen-hua;Zhao Li-rong;Tian Mi;Xiang Yu-ling;Zhou Ben-hong(Department of Pharmacy,Renmin Hospital of Wuhan University,Wuhan 430060,China;School of Pharmaceutical Sciences,Wuhan University,Wuhan 430072,China)

机构地区：[1]武汉大学人民医院药学部,武汉430060 [2]武汉大学药学院,武汉430072

出　　处：《临床肾脏病杂志》2024年第6期507-512,共6页Journal Of Clinical Nephrology

基　　金：国家自然科学基金(31170330)。

摘　　要：肾纤维化是慢性肾脏病的共同病理表现,由于药物递送到肾脏的过程十分复杂,目前尚无有效治疗可以逆转肾纤维化。纳米技术已被广泛应用于医药领域,其靶向性为肾纤维化的诊疗带来了新希望。目前多项研究旨在开发靶向肾脏特定区域、细胞或目标蛋白的递送系统,以期能够解决肾纤维化这一项难题。本综述的目的是对目前肾纤维化诊断、不同靶向策略以及潜在可能治疗肾纤维化的植物提取物的纳米制剂进行总结。Renal fibrosis is a common pathological manifestation of chronic kidney disease(CKD).Since the process of renal drug delivery is rather complex,there is currently no effective remedy for reversing renal fibrosis(RF).Nanotechnology has been widely applied in the field of medicine and its targeting applications bring new hopes for managing RF.Currently numerous studies are aimed at developing delivery systems of targeting specific renal regions,cells or proteins.This review summarized the current diagnoses of RF,different targeting strategies and potential nano-preparations of plant extracts for treating RF.

关 键 词：肾纤维化 纳米递送系统 慢性肾脏病 

分 类 号：R692[医药卫生—泌尿科学]