硫酸吲哚酚与慢性肾脏病肌少症机制的研究进展  

Research advances in the mechanisms of indoxyl sulfate and sarcopenia in chronic kidney disease

作　　者：杨舒媛 张燕[2] 罗琰琨[2] Yang Shu-yuan;Zhang Yan;Luo Yan-kun(The Fifth Clinical Medical College of Shanxi Medical University,Taiyuan 030012,China;Department of Nephrology,Shanxi Provincial People’s Hospital,Taiyuan 030012,China)

机构地区：[1]山西医科大学第五临床医学院,太原030012 [2]山西省人民医院肾内科,太原030012

出　　处：《临床肾脏病杂志》2024年第6期517-520,共4页Journal Of Clinical Nephrology

摘　　要：慢性肾脏病肌少症主要发生在接受血液透析的终末期肾病患者中,病因有营养摄入不足、蛋白能量消耗、炎症细胞因子、氧化应激、胰岛素抵抗、尿毒症毒素等,其中蛋白质结合型尿毒症毒素硫酸吲哚酚是一种肠源性尿毒症毒素,难以通过透析清除,在慢性肾脏病患者体内蓄积,其可通过多种途径影响肌少症的发生。本文将对硫酸吲哚酚引起肌少症的机制进行综述。Sarcopenia in chronic kidney disease(CKD) occurs mainly in patients with end-stage renal disease(ESRD) on hemodialysis.The potential causes are insufficient nutrition intake,protein and energy consumption,inflammatory cytokines,oxidative stress,insulin resistance and uremic toxins.Proteinbound uremic toxin phenol sulfate is an intestinal-derived uremic toxin accumulating in CKD patients.It is difficult to remove through dialysis.It affects the occurrence of sarcopenia through various ways.The review focused upon the mechanisms of sarcopenia caused by indoxyl sulfate.

关 键 词：硫酸吲哚酚 慢性肾脏病 肌少症 

分 类 号：R692[医药卫生—泌尿科学] R685[医药卫生—外科学]