Exploring unconventional attributes of red blood cells and their potential applications in biomedicine  

作　　者：Alkmini T.Anastasiadi Vasiliki-Zoi Arvaniti Krystalyn E.Hudson Anastasios G.Kriebardis Constantinos Stathopoulos Angelo D’Alessandro Steven L.Spitalnik Vassilis L.Tzounakas 

机构地区：[1]Department of Biochemistry,School of Medicine,University of Patras,26504 Patras,Greece [2]Department of Pathology and Cell Biology,Columbia University Irving Medical Center,New York City,NY 10032,USA [3]Laboratory of Reliability and Quality Control in Laboratory Hematology(HemQcR),Department of Biomedical Sciences,School of Health&Caring Sciences,University of West Attica(UniWA),12243 Egaleo,Greece [4]Department of Biochemistry and Molecular Genetics,University of Colorado Anschutz Medical Campus,13001 Aurora,CO,USA [5]Present address:Institute for Fundamental Biomedical Research(IFBR),Biomedical Sciences Research Center“Alexander Fleming”,Vari,11527 Athens,Greece

出　　处：《Protein & Cell》2024年第5期315-330,共16页蛋白质与细胞（英文版）

基　　金：A.T.A.was supported by an EHA Research Grant award granted by the European Hematology Association(RG202212-03039);A.D.was supported by funds by the National Heart,Lung,and Blood Institute(R21HL150032,R01HL146442,R01HL149714,R01HL161004);S.L.S and A.D.were supported by the National Institutes of Health(NIH R01-HL148151).

摘　　要：We need to talk about red blood cells.Eukaryotic cells are defined as cells containing distinct nuclei and other membranous organelles.However,red blood cells(RBCs)lack a nucleus and organelles—perhaps to limit the generation of reactive oxygen species(Zhang et al.,2011)—and are filled with hemoglobin(Hb).This oxygen carrier is limited to the cytosol by the cell membrane and cytoskeleton,which maintain cellular integrity and deformability as RBCs pass through narrow capillaries(Gratzer,1994)to perform their primary function of gas exchange.

关 键 词：MEMBRANOUS MAINTAIN 

分 类 号：R318[医药卫生—生物医学工程]